2. Anti-infection
  3. Antibiotic Bacterial
  4. Levonadifloxacin

Levonadifloxacin  (Synonyms: (S)-(-)-Nadifloxacin; WCK 771)

Cat. No.: HY-14926 Purity: 99.79%
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Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes.

For research use only. We do not sell to patients.

Levonadifloxacin Chemical Structure

Levonadifloxacin Chemical Structure

CAS No. : 154357-42-3

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Based on 1 publication(s) in Google Scholar

Levonadifloxacin Related Antibodies

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Description

Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes[1].

In Vitro

Levonadifloxacin (32 μg/mL; 24 h) achieves a 90-99% intracellular reduction of MSSA and MRSA strains phagocytized in THP-1 monocytes with MICs of 0.03 μg/mL and 15.0 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Levonadifloxacin Related Antibodies
In Vivo

Levonadifloxacin (12.5-400 mg/kg; s.c.; single dose) shows efficacy in vivo against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male/Female Swiss Albino mice (25-28 g) for plasma pharmacokinetic analyses[2]
Dosage: 12.5, 25, 50, 100, 200, 300 and 400 mg/kg
Administration: Subcutaneous injection; single dose; collected samples at 10 time points/dose (0.25, 0.5, 1, 2, 4, 6, 8, 10, 58 12 and 24 h post dose)
Result:
Dose (mg/kg) Cmax (mg/L) AUC0-24 h (mg·h/L) T1/2 (h)
12.5 4.37 7.30 1.79
25 8.71 15.75 1.48
50 19.21 33.36 1.48
100 38.65 70.86 1.76
200 77.29 145.48 1.69
300 92.46 286.19 2.44
400 115.16 393.52 1.74
Clinical Trial
Molecular Weight

360.38

Formula

C19H21FN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN2[C@@H](C)CCC3=C2C(C1=O)=CC(F)=C3N4CCC(O)CC4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (346.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7748 mL 13.8742 mL 27.7485 mL
5 mM 0.5550 mL 2.7748 mL 5.5497 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7748 mL 13.8742 mL 27.7485 mL 69.3712 mL
5 mM 0.5550 mL 2.7748 mL 5.5497 mL 13.8742 mL
10 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9371 mL
15 mM 0.1850 mL 0.9249 mL 1.8499 mL 4.6247 mL
20 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4686 mL
25 mM 0.1110 mL 0.5550 mL 1.1099 mL 2.7748 mL
30 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3124 mL
40 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.7343 mL
50 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3874 mL
60 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
80 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8671 mL
100 mM 0.0277 mL 0.1387 mL 0.2775 mL 0.6937 mL
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Levonadifloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levonadifloxacin154357-42-3(S)-(-)-Nadifloxacin WCK 771WCK771WCK 771WCK-771AntibioticBacterialS. aureusStaphylococcus aureusTHP-1 monocytesMethicillinInhibitorinhibitorinhibit

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