Trimethyloctadecylammonium bromide
Based on 1 Customer Validation
Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1120-02-1
- Formula: C21H46BrN
- Molecular Weight:392.51
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.9 μM (Dynamin I)[1]
Trimethyloctadecylammonium bromide (1 μM-100 μM; 10 min) inhibits EGF-A488 endocytosis in COS-7 cells, with an IC50 value of 16 μM[1].
Trimethyloctadecylammonium bromide (30 μM; 10 min; 37 °C) shows no effect on EGFR activation in A431 cells with insignificant EGFR autophosphorylation change[1].
Trimethyloctadecylammonium bromide (stearyl-) (1 nM-1 mM) inhibits Staphylococcus aureus with of 59.5 nM (CKD assay) and 0.33 mM (CMC assay), respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1120-02-1
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Appearance Solid
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Molecular Weight 392.51
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Formula C21H46BrN
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 10 mg/mL (25.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (758 KB)
- English - EN (758 KB)
- Français - FR (758 KB)
- Deutsch - DE (758 KB)
- Norwegian - NO (758 KB)
- Español - ES (758 KB)
- Swedish - SV (758 KB)
- Italian - IT (758 KB)
- Korean - KR (758 KB)
- Portuguese - PT (758 KB)
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Handling Instructions (2659 KB)
References
[1]. Quan A, et al. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol Pharmacol. 2007 Dec;72(6):1425-39. [Content Brief]
[2]. Baley GJ, et al. Bactericidal properties of quaternary ammonium compounds in dispersed systems. J Pharm Sci. 1977 May;66(5):696-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5477 mL | 12.7385 mL | 25.4771 mL | 63.6926 mL |
| 5 mM | 0.5095 mL | 2.5477 mL | 5.0954 mL | 12.7385 mL | |
| 10 mM | 0.2548 mL | 1.2739 mL | 2.5477 mL | 6.3693 mL | |
| 15 mM | 0.1698 mL | 0.8492 mL | 1.6985 mL | 4.2462 mL | |
| 20 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1846 mL | |
| 25 mM | 0.1019 mL | 0.5095 mL | 1.0191 mL | 2.5477 mL |
Trimethyloctadecylammonium bromide Related Classifications
HY-W013158 Related Classifications
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