1. Anti-infection
  2. Bacterial

Finafloxacin 

Cat. No.: HY-13451
Handling Instructions

Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments.

For research use only. We do not sell to patients.
Finafloxacin Chemical Structure

Finafloxacin Chemical Structure

CAS No. : 209342-40-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $307 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. Target: Antibacterial Finafloxacin is a pH-activated fluoroquinolone (belonging to a new 8-cyano subclass) to treat serious bacterial infections associated with an acidic environment, including urinary tract infections (UTIs) and Helicobacter pylori infections. Finafloxacin exhibits optimal efficacy in slightly acidic environments (pH 5.0-6.0), under which other fluoroquinolones lose activity. Finafloxacin is highly selective for bacterial type II topoisomerases, including DNA gyrase and DNA topoisomerase IV. [1]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01904162 MerLion Pharmaceuticals GmbH Pharmacokinetic and Tolerability of Finafloxacin February 2010 Phase 1
NCT00483158 MerLion Pharmaceuticals GmbH Helicobacter Infections|Urinary Tract Infection August 2007 Phase 1
NCT01907867 MerLion Pharmaceuticals GmbH Safety and Tolerability January 2012 Phase 1
NCT00722735 MerLion Pharmaceuticals GmbH Urinary Tract Infections October 2008 Phase 2
NCT01928433 MerLion Pharmaceuticals GmbH Urinary Tract Infections|Acute Pyelonephritis December 2012 Phase 2
NCT00723502 MerLion Pharmaceuticals GmbH Gram-Negative Bacterial Infections|Helicobacter Infections|Dyspepsia September 2008 Phase 2
NCT01910883 MerLion Pharmaceuticals GmbH Healthy September 2010 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.5101 mL 12.5505 mL 25.1010 mL
5 mM 0.5020 mL 2.5101 mL 5.0202 mL
10 mM 0.2510 mL 1.2551 mL 2.5101 mL
References
M.Wt

398.39

Formula

C₂₀H₁₉FN₄O₄

CAS No.

209342-40-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6.4 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Finafloxacin
Cat. No.:
HY-13451
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