2. Metabolic Enzyme/Protease Anti-infection
  3. Bacterial Dihydrofolate reductase (DHFR)
  4. DHFR-IN-9

DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days).

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DHFR-IN-9 Chemical Structure

DHFR-IN-9 Chemical Structure

CAS No. : 3032441-13-4

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DHFR-IN-9 Related Antibodies

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Description

DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days)[1].

IC50 & Target

IC50: 0.25 μg/mL (MRSA ATCC 43300)[1]
Molecular Weight

360.44

Formula

C19H16N6S
CAS No.
SMILES

NC1=NC2=C(C(N)=N1)C(C=C(C)N3CC4=NC5=CC=CC=C5S4)=C3C=C2
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHFR-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-93032441-13-4BacterialDihydrofolate reductase (DHFR)Biosynthesis of purine and thymidylatemouse model of systemic infectionmouse model of thigh infectionInhibitorinhibitorinhibit

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