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DHFR-IN-9

DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days).

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  • CAS No.: 3032441-13-4
  • Formula: C19H16N6S
  • Molecular Weight:360.44
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • DHFR-IN-9 Chemical Structure
    DHFR-IN-9 Chemical Structure
CAS No.: 3032441-13-4
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  • DHFR-IN-9 Chemical Structure
    DHFR-IN-9 Chemical Structure
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  • DHFR-IN-9