AM8191 hydrochloride
AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM). AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL).
For research use only. We do not sell to patients.
- CAS No.: 1417548-17-4
- Formula: C26H29ClFN5O5
- Molecular Weight:545.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
18 μM
Compound: 6, AM8191
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Inhibition of human ERG expressed in CHO cells by automated patch clamp assay
Inhibition of human ERG expressed in CHO cells by automated patch clamp assay
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[PMID: 24900889] |
Chemical Information
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CAS No. 1417548-17-4
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Molecular Weight 545.99
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Formula C26H29ClFN5O5
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SMILES
O=C1NC2=NC(CNC34CCC(OC3)(CC4)[C@@H](O)CC5=C(F)C=NC6=CC=C(OC)N=C56)=CC=C2OC1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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