1417548-17-4
Chemical Structure
AM8191 hydrochloride
- CAS No.: 1417548-17-4
- Formula:C26H29ClFN5O5
- Molecular Weight:545.99
IUPAC Name: (S)-6-(((1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl)-2-oxabicyclo[2.2.2]octan-4-yl)amino)methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one hydrochloride
InChIKey: WDWFTZSOSPERQG-JKLZSTNZSA-N
SMILES: O=C1NC2=NC(CNC34CCC(OC3)(CC4)[C@@H](O)CC5=C(F)C=NC6=CC=C(OC)N=C56)=CC=C2OC1.Cl
Biological Activity: AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM). AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL)[1].
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AM8191 hydrochloride | AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM). AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL). | |||||||||||||||||||||
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Keywords
