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Cat. No.: HY-121661

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Antibacterial agent 201

Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC₉₉s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively.

For research use only. We do not sell to patients.

CAS No.: 1666171-29-4
Formula: C₄₁H₅₄N₆S₂
Molecular Weight:695.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Antibacterial agent 201 Chemical Structure

CAS No.: 1666171-29-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	GI₅₀	52.2 μM Compound: 10	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay	[PMID: 25684422]

In Vitro

Antibacterial agent 201 (0-100 μg/mL) exhibits cytotoxicity in cancer cells A549 and HEK293T, with CC₅₀s of 64 and 32 μg/mL, respectively^[1].
Antibacterial agent 201 (1-4 μg/mL) interacts synergisticly with Kanamycin (HY-16566)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, HEK293T
Concentration:

0-100 μg/mL
Incubation Time:

48 h
Result:

Exhibited cytotoxicity in A549 and HEK293T.

Chemical Information

CAS No. 1666171-29-4
Molecular Weight 695.04
Formula C₄₁H₅₄N₆S₂
SMILES

S=C(NCC(C1=CC=CC=C1)C2=CC=CC=C2)NCCCNCCCCCNCCCNC(NCC(C3=CC=CC=C3)C4=CC=CC=C4)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang B, et al., Antibacterial Diamines Targeting Bacterial Membranes. J Med Chem. 2016 Apr 14;59(7):3140-51. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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