Antibacterial agent 83
Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes.
For research use only. We do not sell to patients.
- CAS No.: 2413865-92-4
- Formula: C11H5Cl2N3O2
- Molecular Weight:282.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L02 | IC50 |
10.7 μM
Compound: 17h
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Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
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[PMID: 35398730] |
| L02 | IC50 |
3.02 μg/mL
Compound: 17h
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Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay
|
[PMID: 35398730] |
Antibacterial agent 83 (compound 17h) shows antibacterial activity against Newmana, USA300b, and Mu50, with MIC of 0.25 μg/mL all[1].
Antibacterial agent 83 performs poor stability in the liver microsomes of rat, mouse and dog[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413865-92-4
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Molecular Weight 282.08
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Formula C11H5Cl2N3O2
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SMILES
N#CC1=NNC(C(C2=C(C=C(C(Cl)=C2)Cl)O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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