Clindamycin hydrochloride monohydrate
Based on 15 publication(s) in Google Scholar
Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla).
For research use only. We do not sell to patients.
- CAS No.: 58207-19-5
- Formula: C18H36Cl2N2O6S
- Molecular Weight:479.46
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Clindamycin hydrochloride monohydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Acta Pharm Sin B. 2021 Sep;11(9):2850-2858. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- ACS Omega. 2022 Mar 3;7(10):9004-9014. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Dermatol Clin. 2024 September 12.
- Future Microbiol. 2025 Oct 13:1-10. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- bioRxiv. 2026 May 22:2026.05.21.726874. [Abstract]
- bioRxiv. 2024 May 10.
- bioRxiv. 2024 Jan 18.
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
>400 μM
Compound: Clindamycin
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Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
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[PMID: 19075064] |
| HeLa | IC50 |
>400 μg/mL
Compound: Clindamycin
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Antiproliferative effect against HeLa cells after 48 hrs
Antiproliferative effect against HeLa cells after 48 hrs
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[PMID: 17088489] |
| HeLa | IC50 |
200 μg/mL
Compound: Clindamycin
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Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
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[PMID: 17088489] |
| MG-63 | IC50 |
>400 μg/mL
Compound: Clindamycin
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Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
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[PMID: 17088489] |
| MG-63 | IC50 |
250 μg/mL
Compound: Clindamycin
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Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
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[PMID: 17088489] |
| Osteoblast | IC50 |
>400 μg/mL
Compound: Clindamycin
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Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
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[PMID: 17088489] |
| Osteoblast | IC50 |
150 μg/mL
Compound: Clindamycin
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Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
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[PMID: 17088489] |
Chemical Information
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CAS No. 58207-19-5
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Molecular Weight 479.46
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Formula C18H36Cl2N2O6S
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SMILES
CCC[C@H]1CN(C)[C@H](C(N[C@]([C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)([H])[C@H](C)Cl)=O)C1.[H]Cl.[H]O[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Acta Pharm Sin B
Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2. [Abstract]2021 Sep;11(9):2850-2858. PMID: 33723501 -
Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434
Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Water Res. 2023 Jul 15:240:120110. [Abstract]
It can be observed that both PNDIs and PNDPs for several AAs show clear seasonality with high usage in the wet (June-November) and low usage in the dry (December-May) season. This is especially pronounced in the case of sulfonamides and TMP-trimethoprim, macrolides (CLI-clindamycin and CLR-clarithromycin).
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337
Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]
Plumbagin, in combination with the nontetracycline antibiotics gentamycin, erythromycin, clindamycin or polymyxin E, had synergistic or additive effects on E. coli DH5α+pAM401-tet(X3).
Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]
Plumbagin, in combination with the nontetracycline antibiotics gentamycin, erythromycin, clindamycin or polymyxin E, had synergistic or additive effects on E. coli DH5α+pAM401-tet(X4).
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996
Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
SulfurFinder and molecular networking were leveraged to putatively annotate feature #3482 as pirlimycin, which is structurally related to clindamycin with a modified cosine score of 0.83.
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
ACS Omega
Lapatinib Acts against Biofilm Formation and the Hemolytic Activity of Staphylococcus aureus. [Abstract]2022 Mar 3;7(10):9004-9014. PMID: 35309438 -
Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944
Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
Combinations with clindamycin (CLI) and azithromycin (AZM) showed limited or strain-dependent synergy, with most FICI values near or above 0.5.
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Future Microbiol
2025 Oct 13:1-10. PMID: 41082411 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
bioRxiv
Exposure to Antibiotics Modifies the Immune Profiles of Bacterial Extracellular Vesicles from Common Vaginal Anaerobes. [Abstract]2026 May 22:2026.05.21.726874. PMID: 42239425 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clindamycin hydrochloride monohydrate Related Classifications
HY-N7118 Related Classifications
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