Cat. No.: HY-N7118

Clindamycin hydrochloride monohydrate

Name: Clindamycin hydrochloride monohydrate
Brand: MedChemExpress
SKU: HY-N7118
Price: 25.00 USD
Availability: InStock
Rating: 5 (16 reviews)

16 Cited Publications

Customer Review

Based on 16 publication(s) in Google Scholar

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla).

For research use only. We do not sell to patients.

Purity : 98.42%
CAS No.: 58207-19-5
Formula: C₁₈H₃₆Cl₂N₂O₆S
Molecular Weight:479.46

Storage:

RT, protect from light.

In solvent -80°C, 1 year , -20°C, 6 months

Clindamycin hydrochloride monohydrate Chemical Structure

CAS No.: 58207-19-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (16)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
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Biological Activity

Description

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	>400 μM Compound: Clindamycin	Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs	[PMID: 19075064]
HeLa	IC₅₀	>400 μg/mL Compound: Clindamycin	Antiproliferative effect against HeLa cells after 48 hrs Antiproliferative effect against HeLa cells after 48 hrs	[PMID: 17088489]
HeLa	IC₅₀	200 μg/mL Compound: Clindamycin	Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs	[PMID: 17088489]
MG-63	IC₅₀	>400 μg/mL Compound: Clindamycin	Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs	[PMID: 17088489]
MG-63	IC₅₀	250 μg/mL Compound: Clindamycin	Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs	[PMID: 17088489]
Osteoblast	IC₅₀	>400 μg/mL Compound: Clindamycin	Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs	[PMID: 17088489]
Osteoblast	IC₅₀	150 μg/mL Compound: Clindamycin	Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs	[PMID: 17088489]

Chemical Information

CAS No. 58207-19-5
Appearance Powder
Molecular Weight 479.46
Formula C₁₈H₃₆Cl₂N₂O₆S
SMILES

CCC[C@H]1CN(C)[C@H](C(N[C@]([C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)([H])[C@H](C)Cl)=O)C1.[H]Cl.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

RT, protect from light

In solvent	-80°C	1 year
	-20°C	6 months

Publications (16)

All OthersBio/Physico-chemical AssayMicrobiological Assay

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Acta Pharm Sin B

Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2. [Abstract]

2021 Sep;11(9):2850-2858. PMID: 33723501
Water Res

Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]

2023 Jul 15:240:120110. PMID: 37247434

Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Water Res. 2023 Jul 15:240:120110. [Abstract]

It can be observed that both PNDIs and PNDPs for several AAs show clear seasonality with high usage in the wet (June-November) and low usage in the dry (December-May) season. This is especially pronounced in the case of sulfonamides and TMP-trimethoprim, macrolides (CLI-clindamycin and CLR-clarithromycin).
J Exp Med

Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood. [Abstract]

2026 Mar 2;223(3):e20241287. PMID: 41400657
EBioMedicine

A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]

2022 Apr;78:103943. PMID: 35306337

Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]

Plumbagin, in combination with the nontetracycline antibiotics gentamycin, erythromycin, clindamycin or polymyxin E, had synergistic or additive effects on E. coli DH5α+pAM401-tet(X3).

Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]

Plumbagin, in combination with the nontetracycline antibiotics gentamycin, erythromycin, clindamycin or polymyxin E, had synergistic or additive effects on E. coli DH5α+pAM401-tet(X4).
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996

Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]

SulfurFinder and molecular networking were leveraged to putatively annotate feature #3482 as pirlimycin, which is structurally related to clindamycin with a modified cosine score of 0.83.
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
ACS Omega

Lapatinib Acts against Biofilm Formation and the Hemolytic Activity of Staphylococcus aureus. [Abstract]

2022 Mar 3;7(10):9004-9014. PMID: 35309438
Microbiol Spectr

Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]

2025 Oct 15:e0122125. PMID: 41090944

Clindamycin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]

Combinations with clindamycin (CLI) and azithromycin (AZM) showed limited or strain-dependent synergy, with most FICI values near or above 0.5.
Dermatol Clin

2024 September 12.
Future Microbiol

Synergistic drug strategy against mastitis-associated MRSA strains. [Abstract]

2025 Oct 13:1-10. PMID: 41082411
Diagn Microbiol Infect Dis

A rapid bacterial labeling method for phenotypic antimicrobial susceptibility testing. [Abstract]

2026 Feb;114(2):117181. PMID: 41205476
chemRxiv

2026 Jul 2.
bioRxiv

Exposure to Antibiotics Modifies the Immune Profiles of Bacterial Extracellular Vesicles from Common Vaginal Anaerobes. [Abstract]

2026 May 22:2026.05.21.726874. PMID: 42239425
bioRxiv

2024 May 10.
bioRxiv

2024 Jan 18.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (208.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0857 mL

10.4284 mL

20.8568 mL

5 mM

0.4171 mL

2.0857 mL

4.1714 mL

10 mM

0.2086 mL

1.0428 mL

2.0857 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0857 mL	10.4284 mL	20.8568 mL	52.1420 mL
	5 mM	0.4171 mL	2.0857 mL	4.1714 mL	10.4284 mL
	10 mM	0.2086 mL	1.0428 mL	2.0857 mL	5.2142 mL
	15 mM	0.1390 mL	0.6952 mL	1.3905 mL	3.4761 mL
	20 mM	0.1043 mL	0.5214 mL	1.0428 mL	2.6071 mL
	25 mM	0.0834 mL	0.4171 mL	0.8343 mL	2.0857 mL
	30 mM	0.0695 mL	0.3476 mL	0.6952 mL	1.7381 mL
	40 mM	0.0521 mL	0.2607 mL	0.5214 mL	1.3035 mL
	50 mM	0.0417 mL	0.2086 mL	0.4171 mL	1.0428 mL
	60 mM	0.0348 mL	0.1738 mL	0.3476 mL	0.8690 mL
	80 mM	0.0261 mL	0.1304 mL	0.2607 mL	0.6518 mL
	100 mM	0.0209 mL	0.1043 mL	0.2086 mL	0.5214 mL

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Keywords

Clindamycin hydrochloride monohydrate

16 Cited Publications

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Clindamycin hydrochloride monohydrate

Publications Citing Use of MedChemExpress (MCE) Clindamycin hydrochloride monohydrate

All Antibiotic Isoforms