1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Solithromycin

Solithromycin (Synonyms: CEM-101; OP-1068)

Cat. No.: HY-17593 Purity: 99.97%
Handling Instructions

Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC50s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis.

For research use only. We do not sell to patients.

Solithromycin Chemical Structure

Solithromycin Chemical Structure

CAS No. : 760981-83-7

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10 mM * 1 mL in DMSO USD 165 In-stock
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25 mg USD 250 In-stock
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50 mg USD 450 In-stock
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100 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC50s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis[1].

IC50 & Target

Bacterial[1]

In Vitro

The IC50s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM, respectively. Solithromycin markedly reduces MMP9 activity, with an IC50 of 14.9 μM[2].
Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity, and does not affect cell viability in monocytic U937 and PBMC cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (male, 4 weeks)[2]
Dosage: 100 mg/kg
Administration: Oral administration; every day; for 8 days
Result: Inhibited cigarette smoke-induced neutrophilia and pro-MMP9 production.
Clinical Trial
Molecular Weight

845.01

Formula

C₄₃H₆₅FN₆O₁₀

CAS No.
SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (37.87 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1834 mL 5.9171 mL 11.8342 mL
5 mM 0.2367 mL 1.1834 mL 2.3668 mL
10 mM 0.1183 mL 0.5917 mL 1.1834 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SolithromycinCEM-101 OP-1068CEM101CEM 101OP1068OP 1068OP-1068BacterialAntibioticInhibitorinhibitorinhibit

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Solithromycin
Cat. No.:
HY-17593
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