1. Anti-infection
  2. Bacterial
  3. MRL-494 hydrochloride

MRL-494 hydrochloride 

Cat. No.: HY-128773A
Handling Instructions

MRL-494 hydrochloride, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 hydrochloride can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias.

For research use only. We do not sell to patients.

MRL-494 hydrochloride Chemical Structure

MRL-494 hydrochloride Chemical Structure

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Description

MRL-494 hydrochloride, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 hydrochloride can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias[1].

IC50 & Target

β-barrel assembly machine A (BamA)[1]

In Vitro

MRL-494 lethally disrupts the cytoplasmic membrane. MRL-494 inhibits OM proteins (OMPs) biogenesis from outside the outer membrane (OM) by targeting BamA. MRL-494 exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of MRL-494 against E. coli (WT), E. coli (ΔtolC), E. coli (ΔtolC envA101), K. pneumonia, A. baumannii (WT), A. baumannii (ΔlpxC) , P. aeruginosa (efflux deficient), P. aeruginosa (WT), Staphylococcus aureus (methicillin-resistant) and Bacillus subtilis rpoB18 are 25 μM, 25 μM, 25 μM, 100 μM, 200 μM, 200 μM, 100 μM, 100 μM, 12.5 μM and 25 μM, respectively[1].

Molecular Weight

659.12

Formula

C₂₆H₃₆ClFN₁₆O₂

SMILES

FC1=CC=C(C2=NN(CC(N[[email protected]@H]3CC[[email protected]](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (151.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5172 mL 7.5859 mL 15.1717 mL
5 mM 0.3034 mL 1.5172 mL 3.0343 mL
10 mM 0.1517 mL 0.7586 mL 1.5172 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MRL-494MRL494MRL 494BacterialBamAmultidrug-resistantbacteriaeffluxantibacterialInhibitorinhibitorinhibit

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Product Name:
MRL-494 hydrochloride
Cat. No.:
HY-128773A
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