MRL-494 hydrochloride
Based on 1 publication(s) in Google Scholar
MRL-494 hydrochloride, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 hydrochloride can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias.
For research use only. We do not sell to patients.
- Purity: 98.64%
- CAS No.: 2699937-04-5
- Formula: C26H36ClFN16O2
- Molecular Weight:659.12
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MRL-494 hydrochloride
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Biological Activity
β-barrel assembly machine A (BamA)[1]
MRL-494 lethally disrupts the cytoplasmic membrane. MRL-494 inhibits OM proteins (OMPs) biogenesis from outside the outer membrane (OM) by targeting BamA. MRL-494 exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of MRL-494 against E. coli (WT), E. coli (ΔtolC), E. coli (ΔtolC envA101), K. pneumonia, A. baumannii (WT), A. baumannii (ΔlpxC) , P. aeruginosa (efflux deficient), P. aeruginosa (WT), Staphylococcus aureus (methicillin-resistant) and Bacillus subtilis rpoB18 are 25 μM, 25 μM, 25 μM, 100 μM, 200 μM, 200 μM, 100 μM, 100 μM, 12.5 μM and 25 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2699937-04-5
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Appearance Solid
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Molecular Weight 659.12
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Formula C26H36ClFN16O2
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Color White to off-white
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SMILES
FC1=CC=C(C2=NN(CC(N[C@@H]3CC[C@H](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326. [Abstract]2025 Jan;301(1):108018. PMID: 39608713
Solvent & Solubility
H2O : 110 mg/mL (166.89 mM; Need ultrasonic)
DMSO : 100 mg/mL (151.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (37.93 mM); Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.5172 mL | 7.5859 mL | 15.1717 mL | 37.9294 mL |
| 5 mM | 0.3034 mL | 1.5172 mL | 3.0343 mL | 7.5859 mL | |
| 10 mM | 0.1517 mL | 0.7586 mL | 1.5172 mL | 3.7929 mL | |
| 15 mM | 0.1011 mL | 0.5057 mL | 1.0114 mL | 2.5286 mL | |
| 20 mM | 0.0759 mL | 0.3793 mL | 0.7586 mL | 1.8965 mL | |
| 25 mM | 0.0607 mL | 0.3034 mL | 0.6069 mL | 1.5172 mL | |
| 30 mM | 0.0506 mL | 0.2529 mL | 0.5057 mL | 1.2643 mL | |
| 40 mM | 0.0379 mL | 0.1896 mL | 0.3793 mL | 0.9482 mL | |
| 50 mM | 0.0303 mL | 0.1517 mL | 0.3034 mL | 0.7586 mL | |
| 60 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.6322 mL | |
| 80 mM | 0.0190 mL | 0.0948 mL | 0.1896 mL | 0.4741 mL | |
| 100 mM | 0.0152 mL | 0.0759 mL | 0.1517 mL | 0.3793 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MRL-494 hydrochloride Related Classifications
HY-128773A Related Classifications
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