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  3. Benzyldodecyldimethylammonium chloride dihydrate

Benzyldodecyldimethylammonium chloride dihydrate 

Cat. No.: HY-128384
Handling Instructions

Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration.

For research use only. We do not sell to patients.

Benzyldodecyldimethylammonium chloride dihydrate Chemical Structure

Benzyldodecyldimethylammonium chloride dihydrate Chemical Structure

CAS No. : 147228-80-6

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Description

Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration[1][2].

IC50 & Target

MIC: 20 mg/L (P. fluorescens)[1]

In Vitro

Benzyldodecyldimethylammonium chloride dihydrate (1-10 μM; 2 hours) results in a dose-dependent changes in the percent population of dead rat thymocyte cells[1].
Benzyldodecyldimethylammonium chloride dihydrate (0-40 mg/L; 0-24 hours) inhibits P. fluorescens with a MIC of 20 mg/L. At 5 mg/L, cells have the same growth behaviour as the control. At concentrations of 10 and 15 mg/L the growth profile is different from the control, and the cells start to grow only after 8 h of adaptation. At concentrations of ≥20 mg/L, BDMDAC inhibits cell growth[2].
Benzyldodecyldimethylammonium chloride dihydrate interacts strongly with cell surfaces in a concentration-dependent manner, and binds by ionic and hydrophobic interactions to microbial membrane surfaces, as manifested by phenomena such as membrane disruption and loss of membrane integrity with consequent leakage of essential intracellular constituents, which promote significant and irreversible changes in the cell structure[2].

Cell Viability Assay[1]

Cell Line: Rat thymocyte cells
Concentration: 0, 5, 10, 15, 20 and 40 mg/L
Incubation Time: 2 hours
Result: Resulted in cell death.

Cell Proliferation Assay[1]

Cell Line: Bacterial P. fluorescen
Concentration: 0, 5, 10, 15, 20 and 40 mg/L
Incubation Time: 2 hours
Result: Inhibited bacterial growth in a time and dose dependent manner.
Molecular Weight

376.02

Formula

C₂₁H₄₂ClNO₂

CAS No.

147228-80-6

SMILES

C[N+](C)(CCCCCCCCCCCC)CC1=CC=CC=C1.[Cl-].O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Benzyldodecyldimethylammonium chloride dihydrateBacterialDisinfection,?QAC,?BiocideE. coliS. aureusMRSAMDRthymocyteantimicrobialPseudomonas fluorescensInhibitorinhibitorinhibit

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Benzyldodecyldimethylammonium chloride dihydrate
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