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  3. Bacterial
  4. Benzyldodecyldimethylammonium chloride dihydrate

Benzyldodecyldimethylammonium chloride dihydrate 

Cat. No.: HY-128384 Purity: ≥98.0%
COA Handling Instructions

Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration.

For research use only. We do not sell to patients.

Benzyldodecyldimethylammonium chloride dihydrate Chemical Structure

Benzyldodecyldimethylammonium chloride dihydrate Chemical Structure

CAS No. : 147228-80-6

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration[1][2].

IC50 & Target

MIC: 20 mg/L (P. fluorescens)[1]
In Vitro

Benzyldodecyldimethylammonium chloride dihydrate (1-10 μM; 2 hours) results in a dose-dependent changes in the percent population of dead rat thymocyte cells[1].
Benzyldodecyldimethylammonium chloride dihydrate (0-40 mg/L; 0-24 hours) inhibits P. fluorescens with a MIC of 20 mg/L. At 5 mg/L, cells have the same growth behaviour as the control. At concentrations of 10 and 15 mg/L the growth profile is different from the control, and the cells start to grow only after 8 h of adaptation. At concentrations of ≥20 mg/L, BDMDAC inhibits cell growth[2].
Benzyldodecyldimethylammonium chloride dihydrate interacts strongly with cell surfaces in a concentration-dependent manner, and binds by ionic and hydrophobic interactions to microbial membrane surfaces, as manifested by phenomena such as membrane disruption and loss of membrane integrity with consequent leakage of essential intracellular constituents, which promote significant and irreversible changes in the cell structure[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rat thymocyte cells
Concentration: 0, 5, 10, 15, 20 and 40 mg/L
Incubation Time: 2 hours
Result: Resulted in cell death.

Cell Proliferation Assay[1]

Cell Line: Bacterial P. fluorescen
Concentration: 0, 5, 10, 15, 20 and 40 mg/L
Incubation Time: 2 hours
Result: Inhibited bacterial growth in a time and dose dependent manner.
Molecular Weight

376.02

Appearance

Solid

Formula

C21H42ClNO2
CAS No.
SMILES

C[N+](C)(CCCCCCCCCCCC)CC1=CC=CC=C1.[Cl-].O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (265.94 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (265.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6594 mL 13.2972 mL 26.5943 mL
5 mM 0.5319 mL 2.6594 mL 5.3189 mL
10 mM 0.2659 mL 1.3297 mL 2.6594 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Benzyldodecyldimethylammonium chloride dihydrate147228-80-6BacterialDisinfection,?QAC,?BiocideE. coliS. aureusMRSAMDRthymocyteantimicrobialPseudomonas fluorescensInhibitorinhibitorinhibit

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