1. Anti-infection
  2. Bacterial
  3. Ceftaroline fosamil

Ceftaroline fosamil (Synonyms: TAK-599; PPI0903)

Cat. No.: HY-14737 Purity: 98.28%
Handling Instructions

Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

For research use only. We do not sell to patients.

Ceftaroline fosamil Chemical Structure

Ceftaroline fosamil Chemical Structure

CAS No. : 400827-46-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 344 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

In Vivo

Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% fT>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log10 kill[1]. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log10 CFU[2].

Clinical Trial
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (40.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3428 mL 6.7138 mL 13.4275 mL
5 mM 0.2686 mL 1.3428 mL 2.6855 mL
10 mM 0.1343 mL 0.6714 mL 1.3428 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (2.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (2.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (2.91 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Seventeen clinical S. aureus isolates (2 MSSA, 15 MRSA) are studied using the neutropenic lung infection model. Beginning 3 h after inoculation, groups of six mice receive treatment with Ceftaroline fosamil over a 24 h period. Ceftaroline fosamil doses are administered as 0.2 mL subcutaneous injections. Control animals are administered normal saline at the same volume, route, and frequency as the treatment regimens[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

744.74

Formula

C₂₄H₂₅N₈O₁₀PS₄

CAS No.

400827-46-5

SMILES

O=C1[[email protected]@H](NC(/C(C2=NSC(NP(O)(O)=O)=N2)=N\OCC)=O)[[email protected]@]3([H])SCC(SC4=NC(C5=CC=[N+](C)C=C5)=CS4)=C(C(O)=O)N13.CC([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.28%

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Product Name:
Ceftaroline fosamil
Cat. No.:
HY-14737
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Ceftaroline fosamil

Cat. No.: HY-14737