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Cat. No.: HY-14366

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Antibiotic A-33853

Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively.

For research use only. We do not sell to patients.

CAS No.: 80148-45-4
Formula: C₂₀H₁₃N₃O₆
Molecular Weight:391.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Antibiotic A-33853 Chemical Structure

CAS No.: 80148-45-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	14.2 μM Compound: 31	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 18989953]

In Vitro

Antibiotic A-33853 shows inhibitory effect against the protozoan organism Eimeria tenella (major causative or ganism of coccidiosis), and inhibits Trichomonas vaginalis with an MIC value of <0.975 ug/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibiotic A-33853 (60 mg/kg; s.c.; single dose) is inactive against Mycoplasma gallisepticum in chicks in vivo^[1].
Antibiotic A-33853 (70 mg/kg; s.c.; twice doses) is ineffective against S. aureus in mice in vivo^[1].
Antibiotic A-33853 has an acute toxic dose with a LD₅₀ value >300 mg/kg (i.p.) on mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 80148-45-4
Molecular Weight 391.33
Formula C₂₀H₁₃N₃O₆
SMILES

O=C(C1=C2N=C(C3=CC=CC(O)=C3NC(C4=NC=CC=C4O)=O)OC2=CC=C1)O
Initial Source

Streptomyces NRRL 12068.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes J. Med. Chem., 2008, 51 (23), pp 7344-7347

[2]. Michel KH, et al. The discovery, fermentation, isolation, and structure of antibiotic A33853 and its tetraacetyl derivative. J Antibiot (Tokyo). 1984 May;37(5):441-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Antibiotic A-33853

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antibiotic A-33853 Related Classifications

HY-14366 Related Classifications