Anti-MRSA agent 26
Anti-MRSA agent 26 is a potent anti-MRSA agent with MIC <0.015 μg/mL. Anti-MRSA agent 26 has superior activity against a broad range of Gram-positive pathogens and shows no cytotoxicity in three mammalian cell lines (Caco-2, DU-145 and MDCKII MDR1 cells) at 10 μM. Anti-MRSA agent 26 has a robust TAP pharmacophore and an excellent antibacterial activity in Staphylococcus aureus skin infection mice model.
For research use only. We do not sell to patients.
- Formula: C36H44N8O4
- Molecular Weight:652.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Anti-MRSA agent 26 (Compound 21) (1-10 μM, 3 h) does not cause toxicity in Caco-2, DU-145 and MDCKII MDR1 cells at concentrations 10 μM[1].
Anti-MRSA agent 26 (0.015-16 μg/mL, 20-24 h) has superior activity against a broad range of Gram-positive pathogens, with MICs of <0.015 μg/mL (MRSE), 0.015-0.03 μg/mL (MRSA, VRE1, VRE5), and 0.06 μg/mL (MSSA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 cells, DU-145 cells and MDCKII MDR1 cells
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Concentration:1 μM and 10 μM
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Incubation Time:3 h
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Result:Did not cause toxicity in Caco-2, DU-145 and MDCKII MDR1 cells at concentrations 10 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/cJRj mice were inoculated with 5 μL of Staphylococcus aureus ATCC 29213 (5 × 103 CFU/mouse) on skin lesion (10 × 10 mm) on day 0[1].
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Dosage:2% cream
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Administration:Applied the cream to cover the wound, twice per day with 6 h between for 5 days and then collected skin tissue and bacteria.
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Result:Significantly reduced Staphylococcus aureus load in Staphylococcus aureus skin infection mice model.
Chemical Information
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Molecular Weight 652.79
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Formula C36H44N8O4
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SMILES
O=C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@]2(CCC3=O)[C@]3([H])[C@@]1(C)[C@H](C)CC2)CN(N=N4)C=C4C5=CC=C(CN6C=CC7=C6N=CN=C7N)N=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Christoffer V Heidtmann, et al. Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins. J Med Chem. 2025 May 8;68(9):9479-9500. [Content Brief]
[2]. Heidtmann CV, et al. Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins. J Med Chem. 2025 May 8;68(9):9479-9500. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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