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Cat. No.: HY-186107

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ZY36

ZY36 is a SaClpP agonist with an EC₅₀ of 1.01 μM against Staphylococcus aureus. ZY36 activates SaClpP-mediated proteolysis. ZY36 inhibits the growth of Staphylococcus aureus. ZY36 is applicable to studies related to Staphylococcus aureus infections, such as peritonitis.

For research use only. We do not sell to patients.

Formula: C₂₇H₃₂F₄N₄O₃
Molecular Weight:536.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZY36 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

ZY36 activates purified S. aureus ClpP-mediated α-casein hydrolysis with an EC₅₀ of 1.01 ± 0.2 μM^[1].
ZY36 inhibits the growth of S. aureus Newman with an MIC of 0.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 536.56
Formula C₂₇H₃₂F₄N₄O₃
SMILES

O=C(N(CCC1=O)[C@@]([H])(CN2CC3=C4C=CC=CC4=C(F)C=C3)N1[C@@H]([C@@H](C)CC)C2=O)NCCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Zymosan-Induced Peritonitis
Zymosan-induced peritonitis is a sterile acute-inflammation model produced by intraperitoneal injection of zymosan, a yeast cell-wall particle preparation, followed by quantification of leukocyte recruitment and soluble inflammatory mediators in peritoneal lavage fluid. Low-dose zymosan peritonitis is commonly used as a self-resolving acute inflammation model in which neutrophil recruitment occurs early and monocyte/macrophage accumulation follows later. The assay readouts include total peritoneal leukocyte number, differential neutrophil and monocyte/macrophage counts, peritoneal cytokines and chemokines, plasma or peritoneal exudation, and optional lipidomic or metabolomic changes during inflammation and resolution. Early neutrophil recruitment after zymosan depends strongly on complement and mast-cell C5a receptor signaling, whereas later monocyte recruitment is linked to MCP-1/CCL2 production.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang T, et al. Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection. J Med Chem. 2025 Jan 23;68(2):1810-1823. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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