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Cat. No.: HY-186107

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ZY36

ZY36 is a SaClpP agonist with an EC₅₀ of 1.01 μM against Staphylococcus aureus. ZY36 activates SaClpP-mediated proteolysis. ZY36 inhibits the growth of Staphylococcus aureus. ZY36 is applicable to studies related to Staphylococcus aureus infections, such as peritonitis.

For research use only. We do not sell to patients.

Formula: C₂₇H₃₂F₄N₄O₃
Molecular Weight:536.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZY36 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

ZY36 activates purified S. aureus ClpP-mediated α-casein hydrolysis with an EC₅₀ of 1.01 ± 0.2 μM^[1].
ZY36 inhibits the growth of S. aureus Newman with an MIC of 0.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 536.56
Formula C₂₇H₃₂F₄N₄O₃
SMILES

O=C(N(CCC1=O)[C@@]([H])(CN2CC3=C4C=CC=CC4=C(F)C=C3)N1[C@@H]([C@@H](C)CC)C2=O)NCCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang T, et al. Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection. J Med Chem. 2025 Jan 23;68(2):1810-1823. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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