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United States

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Cat. No.: HY-P11471

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(K(C10)GGGRrRPC)2

(K(C10)GGGRrRPC)2 (Compound (C-C10)C-C) is a dimeric lipopeptide and antibacterial agent. (K(C10)GGGRrRPC)2 enhances the accumulation of ROS, inhibits the bacterial respiratory chain dehydrogenase activity. (K(C10)GGGRrRPC)2 exhibits significant inhibition of bacterial biofilm formation. (K(C10)GGGRrRPC)2 exhibits antimicrobial activity against Acinetobacter baumannii AB1901, A. baumannii AB1902, Pseudomonas aeruginosa 25349, Staphylococcus aureus 11011, with MICs of 4 μM, 8 μM, 4 μM, and 8 μM, respectively. (K(C10)GGGRrRPC)2 shows antimicrobial efficacy against E. coli ATCC 25922.

For research use only. We do not sell to patients.

Formula: C₉₆H₁₇₆N₃₈O₂₂S₂
Molecular Weight:2278.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(K(C10)GGGRrRPC)2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 2278.80
Formula C₉₆H₁₇₆N₃₈O₂₂S₂
Sequence

{Lys(decanal)}-Gly-Gly-Gly-Arg-{d-Arg}-Arg-Pro-Cys-Cys-Pro-Arg-{d-Arg}-Arg-Gly-Gly-Gly-{Lys(decanal)} (Disulfide bridge: Cys9-Cys10)
Sequence Shortening

{Lys(decanal)}-GGGR-{d-Arg}-RRPCCPRR-{d-Arg}-RGGG-{Lys(decanal)} (Disulfide bridge: Cys9-Cys10)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan X, et al. Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections. J Med Chem. 2025 Jan 23;68(2):1397-1416. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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