Search Result

Results for "

active protein kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) AAK1 (6) Acetyl-CoA Carboxylase (1) Akt (16) AMPK (22) Anaplastic lymphoma kinase (ALK) (14) Androgen Receptor (5) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) AP-1 (1) Apoptosis (33) ATM/ATR (1) Aurora Kinase (2) Autophagy (12) Bacterial (2) Bcl-2 Family (5) Bcr-Abl (13) BCRP (3) Btk (3) c-Kit (15) c-Met/HGFR (12) Cadherin (1) Calcium Channel (8) CaMK (13) Cannabinoid Receptor (1) Casein Kinase (1) Caspase (8) CDK (49) Cholinesterase (ChE) (3) COX (2) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) DAPK (1) DGK (2) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (2) DNA-PK (6) DNA/RNA Synthesis (4) DOCK (3) Drug Isomer (1) DYRK (2) EGFR (22) Endogenous Metabolite (3) Ephrin Receptor (1) Epigenetic Reader Domain (1) ERK (10) Eukaryotic Initiation Factor (eIF) (2) FAK (3) Ferroptosis (1) FGFR (23) FLT3 (4) Fructose-1,6-bisphosphate aldolase (1) G Protein-coupled Receptor Kinase (GRK) (3) GLUT (1) Glutathione Peroxidase (1) Glycosidase (1) GSK-3 (3) Haspin Kinase (1) HDAC (1) Hippo (MST) (2) HIV (4) HSP (1) IAP (1) IFNAR (2) IGF-1R (3) IKK (2) Influenza Virus (1) Insulin Receptor (2) Interleukin Related (7) IRAK (2) Isotope-Labeled Compounds (5) Itk (1) JAK (10) JNK (10) Keap1-Nrf2 (2) LIM Kinase (LIMK) (1) Lipase (1) LRRK2 (2) MAP3K (2) MAP4K (2) MAPKAPK2 (MK2) (1) MASTL (1) MDM-2/p53 (1) MEK (8) Mitochondrial Metabolism (2) Mixed Lineage Kinase (2) MNK (5) Molecular Glues (5) mTOR (7) Na+/K+ ATPase (1) Necroptosis (1) NF-κB (8) NO Synthase (4) Nucleoside Antimetabolite/Analog (2) Organoid (3) P-glycoprotein (1) p38 MAPK (10) Parasite (6) PARP (4) PDGFR (5) Phosphodiesterase (PDE) (1) PI3K (9) PI4K (2) Pim (2) PKA (12) PKC (36) PKD (1) PKG (2) Polo-like Kinase (PLK) (1) PPAR (2) PROTACs (1) Protease Activated Receptor (PAR) (1) Proton Pump (5) Pyruvate Kinase (3) Raf (2) Reactive Oxygen Species (ROS) (8) Reference Standards (13) RET (18) Ribosomal S6 Kinase (RSK) (2) RIP kinase (6) ROCK (9) ROS Kinase (2) Salt-inducible Kinase (SIK) (1) SARS-CoV (1) Ser/Thr Kinase (4) SGK (1) Sirtuin (3) SphK (2) Src (9) SRPK (3) STAT (3) Tau Protein (1) TGF-β Receptor (3) Tie (3) TNF Receptor (3) TNK1 (1) Toll-like Receptor (TLR) (1) TOPK (6) Trk Receptor (5) Tyrosinase (1) ULK (1) VEGFR (6) Wee1 (1) WNK Kinase (2) Wnt (3) β-catenin (3)
By Research Areas:	Cancer (308) Cardiovascular Disease (21) Endocrinology (2) Infection (11) Inflammation/Immunology (57) Metabolic Disease (31) Neurological Disease (38)

By Targets:

11β-HSD (1)

AAK1 (6)

Acetyl-CoA Carboxylase (1)

Akt (16)

AMPK (22)

Anaplastic lymphoma kinase (ALK) (14)

Androgen Receptor (5)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

AP-1 (1)

Apoptosis (33)

ATM/ATR (1)

Aurora Kinase (2)

Autophagy (12)

Bacterial (2)

Bcl-2 Family (5)

Bcr-Abl (13)

BCRP (3)

Btk (3)

c-Kit (15)

c-Met/HGFR (12)

Cadherin (1)

Calcium Channel (8)

CaMK (13)

Cannabinoid Receptor (1)

Casein Kinase (1)

Caspase (8)

CDK (49)

Cholinesterase (ChE) (3)

COX (2)

Cyclin G-associated Kinase (GAK) (1)

Cytochrome P450 (2)

DAPK (1)

DGK (2)

Dihydroorotate Dehydrogenase (1)

Discoidin Domain Receptor (2)

DNA-PK (6)

DNA/RNA Synthesis (4)

DOCK (3)

Drug Isomer (1)

DYRK (2)

EGFR (22)

Endogenous Metabolite (3)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

ERK (10)

Eukaryotic Initiation Factor (eIF) (2)

FAK (3)

Ferroptosis (1)

FGFR (23)

FLT3 (4)

Fructose-1,6-bisphosphate aldolase (1)

G Protein-coupled Receptor Kinase (GRK) (3)

GLUT (1)

Glutathione Peroxidase (1)

Glycosidase (1)

GSK-3 (3)

Haspin Kinase (1)

HDAC (1)

Hippo (MST) (2)

HIV (4)

HSP (1)

IAP (1)

IFNAR (2)

IGF-1R (3)

IKK (2)

Influenza Virus (1)

Insulin Receptor (2)

Interleukin Related (7)

IRAK (2)

Isotope-Labeled Compounds (5)

Itk (1)

JAK (10)

JNK (10)

Keap1-Nrf2 (2)

LIM Kinase (LIMK) (1)

Lipase (1)

LRRK2 (2)

MAP3K (2)

MAP4K (2)

MAPKAPK2 (MK2) (1)

MASTL (1)

MDM-2/p53 (1)

MEK (8)

Mitochondrial Metabolism (2)

Mixed Lineage Kinase (2)

MNK (5)

Molecular Glues (5)

mTOR (7)

Na+/K+ ATPase (1)

Necroptosis (1)

NF-κB (8)

NO Synthase (4)

Nucleoside Antimetabolite/Analog (2)

Organoid (3)

P-glycoprotein (1)

p38 MAPK (10)

Parasite (6)

PARP (4)

PDGFR (5)

Phosphodiesterase (PDE) (1)

PI3K (9)

PI4K (2)

Pim (2)

PKA (12)

PKC (36)

PKD (1)

PKG (2)

Polo-like Kinase (PLK) (1)

PPAR (2)

PROTACs (1)

Protease Activated Receptor (PAR) (1)

Proton Pump (5)

Pyruvate Kinase (3)

Raf (2)

Reactive Oxygen Species (ROS) (8)

Reference Standards (13)

RET (18)

Ribosomal S6 Kinase (RSK) (2)

RIP kinase (6)

ROCK (9)

ROS Kinase (2)

Salt-inducible Kinase (SIK) (1)

SARS-CoV (1)

Ser/Thr Kinase (4)

SGK (1)

Sirtuin (3)

SphK (2)

Src (9)

SRPK (3)

STAT (3)

Tau Protein (1)

TGF-β Receptor (3)

Tie (3)

TNF Receptor (3)

TNK1 (1)

Toll-like Receptor (TLR) (1)

TOPK (6)

Trk Receptor (5)

Tyrosinase (1)

ULK (1)

VEGFR (6)

Wee1 (1)

WNK Kinase (2)

Wnt (3)

β-catenin (3)

By Research Areas:

Cancer (308)

Cardiovascular Disease (21)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (57)

Metabolic Disease (31)

Neurological Disease (38)

412

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

410

Recombinant Proteins

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-147312

GSK-1520489A	Wee1	Cancer
GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC₅₀=115 nM, K_i=10.94 nM) .

HY-E70805

Biotin-SRPK2 Recombinant Human Active Protein Kinase	SRPK	Cancer
SRPK2 (serine-arginine protein kinase 2) is a protein kinase that is involved in cell cycle regulation and cell apoptosis. Biotin-SRPK2 Recombinant Human Active Protein Kinase is a recombinant SRPK2 protein that can be used to study SRPK2-related functions, and is biotinylated .

HY-E70653

CDK1/CycB1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycB1 Recombinant Human Active Protein Kinase is an ortholog of CDK1. CDK1/cyclin B1 complexes initiates mitotic entry by phosphorylating a multitude of proteins to condense chromosomes, disrupt the nuclear envelope, and enable microtubules polymerization to attach and to segregate the chromosomes .

HY-E70648

AMPK alpha 1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK alpha 1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1 proteins .

HY-E70863

SRPK1 Recombinant Human Active Protein Kinase	SRPK	Cancer
SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. SRPK1 Recombinant Human Active Protein Kinase is a recombinant SRPK1 protein that can be used to study SRPK1-related functions .

HY-E70833

ITK Recombinant Human Active Protein Kinase	Itk	Cancer
ITK is the Tec family tyrosine kinase that has been implicated in T cell receptor (TCR) signaling. ITK Recombinant Human Active Protein Kinase is a recombinant ITK protein that can be used to study ITK-related functions .

HY-E70728

HRI Recombinant Human Active Protein Kinase	Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology
Heme-regulated inhibitory (HRI) is an eIF2α kinase, which induces a cytosolic unfolded protein response to prevent aggregation of innate immune signalosomes. HRI Recombinant Human Active Protein Kinase is a recombinant HRI protein that can be used to study HRI-related functions .

HY-E70868

TNK1 Recombinant Human Active Protein Kinase	TNK1	Cancer
Thirty-eight-negative kinase-1 (TNK1) is a member of the ACK family of NRTKs, which includes only two human kinases, TNK1 and TNK2 (also called ACK1). TNK1 Recombinant Human Active Protein Kinase is a recombinant TNK1 protein that can be used to study TNK1-related functions .

HY-E70830

HIPK2 Recombinant Human Active Protein Kinase	DYRK	Cancer
Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals. HIPK2 Recombinant Human Active Protein Kinase is a recombinant HIPK2 protein that can be used to study HIPK2-related functions .

HY-E70852

PKCα Recombinant Human Active Protein Kinase	PKC	Cancer
PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions .

HY-E70861

SIK1 Recombinant Human Active Protein Kinase	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIK1 is a MAP4 kinase. The SIK1 MAP4K regulates cell proliferation and cell expansion. SIK1 phosphorylates BIK1 and stabilizes it in a kinase activity-dependent manner. SIK1 Recombinant Human Active Protein Kinase is a recombinant SIK1 protein that can be used to study SIK1-related functions .

HY-E70743

MASTL Recombinant Human Active Protein Kinase	MASTL	Cancer
MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. MASTL Recombinant Human Active Protein Kinase is a recombinant MASTL protein that can be used to study MASTL-related functions .

HY-E70832

IRR Recombinant Human Active Protein Kinase	Insulin Receptor	Metabolic Disease
IRR is a member of the insulin receptor (IR) family. IRR activation by alkali is determined by its N-terminal extracellular region. IRR Recombinant Human Active Protein Kinase is a recombinant IRR protein that can be used to study IRR-related functions .

HY-E70871

TTBK2 Recombinant Human Active Protein Kinase	Tau Protein	Neurological Disease
TTBK2 is a tau tubulin kinase. Mutations in TTBK2 cause spinocerebellar ataxia type 11, a disorder exhibiting both loss of Purkinje cells and widespread deposition of tau. TTBK2 Recombinant Human Active Protein Kinase is a recombinant TTBK2 protein that can be used to study TTBK2-related functions .

HY-E70746

MEK1 SESE Recombinant Human Active Protein Kinase	MEK	Cancer
MEK1 is the MAP/ERK kinase. The MEK1 kinase directly phosphorylates ERK2, after the activation loop of MEK1 is itself phosphorylated by Raf. MEK1 SESE is a mutant of MEK1. MEK1 SESE Recombinant Human Active Protein Kinase is a recombinant MEK1 SESE protein that can be used to study MEK1 SESE-related functions .

HY-E70649

BRAF V600E Recombinant Human Active Protein Kinase	Raf	Cancer
BRAF is a member of the Raf kinase family of growth signal transduction protein kinases. BRAF has multiple mutants. BRAF V600E is commonly found in melanoma. BRAF V600E Recombinant Human Active Protein Kinase is a recombinant BRAF V600E protein that can be used to study BRAF V600E-related functions .

HY-E70660

CDK13/CycK Recombinant Human Active Protein Kinase	CDK	Cancer
CDK13/CycK Recombinant Human Active Protein Kinase is a RNA polymerase II C-terminal domain kinases. CDK13 interacts with the splicing factor SRSF1 and to regulate alternative splicing of HIV .

HY-E70672

CDK2/CycE1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK2 is a cyclin-dependent kinase involved in the control of the cell cycle. CDK2/CycE1 Recombinant Human Active Protein Kinase is an ortholog of CDK2 .

HY-E70869

TRKA(NTRK1) Recombinant Human Active Protein Kinase	Trk Receptor	Neurological Disease
TRKA (also named NTRK1) is a potential new member of the tyrosine kinase gene family. TRKA is a receptor tyrosine kinase that is phosphorylated in response to NGF. A single transmembrane domain divides TRKA into an extracellular domain, important for NGF binding, and an intracellular tyrosine kinase domain, important for signal transduction. TRKA(NTRK1) Recombinant Human Active Protein Kinase is a recombinant TRKA(NTRK1) protein that can be used to study TRKA(NTRK1)-related functions .

HY-E70844

MAP2K2 Recombinant Human Active Protein Kinase	MEK	Cancer
MAP2K2 (MEK2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. MAP2K2 phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. MAP2K2 Recombinant Human Active Protein Kinase is a recombinant MAP2K2 protein that can be used to study MAP2K2-related functions .

HY-E70839

KHS1 Recombinant Human Active Protein Kinase	Ser/Thr Kinase	Cancer
MAP4K5 (KHS1) belongs to the mammalian Ste20-like serine/threonine kinase family. MAP4K5 plays an important role in regulating a range of cellular responses and is involved in Wnt signaling in hematopoietic cells. KHS1 Recombinant Human Active Protein Kinase is a recombinant KHS1 protein that can be used to study KHS1-related functions .

HY-E70659

CDK12/CycK Recombinant Human Active Protein Kinase	CDK	Cancer
CDK12/CycK Recombinant Human Active Protein Kinase is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of RNA polymerase II (Pol II), thereby regulating different phases of the transcription cycle from transcription initiation to elongation and termination .

HY-E70856

PKCθ Recombinant Human Active Protein Kinase	PKC	Inflammation/Immunology
PKCθ is a member of the Ca ²⁺-independent PKC subfamily. PKCθ plays an important role in T cell activation. PKCθ is also required for the survival of activated peripheral T lymphocytes. PKCθ Recombinant Human Active Protein Kinase is a recombinant PKCθ protein that can be used to study PKCθ-related functions .

HY-E70870

TRKB(NTRK2) Recombinant Human Active Protein Kinase	Trk Receptor	Neurological Disease
TRKB(NTRK2) is a member of tyrosine kinase gene family. TRKB is the primary receptor for brain-derived nerve growth factor (BDNF) and neurotrophin 4/5 (NT4/5). TRKB(NTRK2) Recombinant Human Active Protein Kinase is a recombinant TRKB(NTRK2) protein that can be used to study TRKB(NTRK2)-related functions .

HY-E70730

INSR Recombinant Human Active Protein Kinase	IGF-1R	Metabolic Disease
The whole IGF axis constitutes an interactive network composed of the peptide-ligands IGF1, IGF2 and insulin, and the receptors IGF1R, IGF2R and insulin receptor (INSR) as IGF binding proteins (IGFBPs). The INSR itself appears in two isoforms, INSRA and INSRB differing in 12 amino acids encoded by exon 11. INSR Recombinant Human Active Protein Kinase is a recombinant INSR protein that can be used to study INSR-related functions .

HY-E70763

PDGFRalpha T674I Recombinant Human Active Protein Kinase	PDGFR	Cancer
PDGFRalpha is a receptor tyrosine kinases that stimulate cell survival, proliferation and motility. Upon PDGF binding, the receptor dimerizes and undergoes a conformational change, which activates the kinase domain. PDGFRalpha T674I is a mutant of PDGFRalpha. PDGFRalpha T674I Recombinant Human Active Protein Kinase is a recombinant PDGFRalpha T674I protein that can be used to study PDGFRalpha T674I-related functions .

HY-E70729

ICK Recombinant Human Active Protein Kinase	Ser/Thr Kinase	Metabolic Disease
The intestinal cell kinase (ICK) protein belongs to the ros-cross hybridizing kinase (RCK) family. ICK is a ciliary protein, involved in ciliogenesis and regulation of intraflagellar transport (IFT). ICK Recombinant Human Active Protein Kinase is a recombinant ICK protein that can be used to study ICK-related functions .

HY-E70725

FRK Recombinant Human Active Protein Kinase	Src	Cancer
FRK Recombinant Human Active Protein Kinase, a non-receptor tyrosine kinase Fyn-related kinase, is a member of the BRK family kinases (BFKs). FRK may be involved in tumor progression .

HY-E70858

QIK Recombinant Human Active Protein Kinase	AMPK	Cancer
QIK belongs to the AMPK/SNF1 kinase family. It is a ubiquitously expressed protein and is upregulated rapidly after a hormone-regulated form of Qin is activated. QIK Recombinant Human Active Protein Kinase is a recombinant QIK protein that can be used to study QIK-related functions .

HY-E70788

BARK1 Recombinant Human Active Protein Kinase	Ser/Thr Kinase	Others
BARK1 Recombinant Human Active Protein Kinase is a membrane LRR-RLK (leucine-rich repeat receptor-like kinase) protein that specifically binds to BAK1 and its homologs .

HY-E70804

Biotin-SRPK1 Recombinant Human Active Protein Kinase	SRPK	Cancer
SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. Biotin-SRPK1 Recombinant Human Active Protein Kinase is a recombinant SRPK1 protein that can be used to study SRPK1-related functions, and is biotinylated .

HY-E70840

KIT Recombinant Human Active Protein Kinase	c-Kit	Cancer
Kit is a type III receptor protein-tyrosine kinase. Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. KIT Recombinant Human Active Protein Kinase is a recombinant KIT protein that can be used to study KIT-related functions .

HY-E70798

Biotin-ERK2 Recombinant Human Active Protein Kinase	ERK	Cancer
ERK2 is a serine/threonine-specific protein kinase capable of phosphorylating multiple protein substrates within a cell. Biotin-ERK2 Recombinant Human Active Protein Kinase is obtained by expressing ERK2 proteins and is biotinylated .

HY-E70656

CDK1/CycO Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycO Recombinant Human Active Protein Kinase is an ortholog of CDK1 .

HY-E70712

EIF2AK4 Recombinant Human Active Protein Kinase	Eukaryotic Initiation Factor (eIF)	Cancer
EIF2AK4 Recombinant Human Active Protein Kinase belongs to a family of kinases that regulate angiogenesis in response to cellular stress. EIF2AK4 Recombinant Human Active Protein Kinase can be used for the study of pulmonary capillary hemangiomatosis (PCH) .

HY-E70692

CLK3 Recombinant Human Active Protein Kinase	CDK	Cancer
CLK3 is a nuclear dual-specificity kinase has been shown to undergo conserved alternative splicing to generate catalytically active (Clk) and inactive (ClkT) isoforms. CLK3 Recombinant Human Active Protein Kinase is a recombinant CLK3 protein that can be used to study CLK3-related functions .

HY-E70806

Biotin-WNK1 Recombinant Human Active Protein Kinase	WNK Kinase	Cancer
WNK1 is a WNK kinase that is involved in embryonic angiogenesis and tumor-induced angiogenesis. Biotin-WNK1 Recombinant Human Active Protein Kinase is obtained by expressing WNK1 proteins and is biotinylated .

HY-E70813

CAMKK2 Recombinant Human Active Protein Kinase	CaMK	Neurological Disease
CaMKK2 is a serine/threonine protein kinase and the central component of a Ca ²⁺-calmodulin activated signalling pathway. CaMKK2 is highly enriched in brain neurons and regulates energy metabolism and neuronal processes. CAMKK2 Recombinant Human Active Protein Kinase is obtained by expressing CAMKK2 proteins .

HY-E70655

CDK1/CycE2 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycE2 Recombinant Human Active Protein Kinase is an ortholog of CDK1 .

HY-E70651

CDK1/CycA1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycA1 Recombinant Human Active Protein Kinase is an ortholog of CDK1 .

HY-E70654

CDK1/CycE1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycA1 Recombinant Human Active Protein Kinase is an ortholog of CDK1 .

HY-E70657

CDK10/CycQ Recombinant Human Active Protein Kinase	CDK	Neurological Disease Cancer
CDK10/CycQ Recombinant Human Active Protein Kinase is a cyclin-dependent kinase, which is important for neural development and can act as a tumour suppressor .

HY-E70667

CDK18/CycY Recombinant Human Active Protein Kinase	CDK	Neurological Disease
CDK18 is a neuronal kinase that phosphorylates TAU protein when overexpressed in human brain. CDK18 shares a conserved PCTAIRE amino acid sequence in the helical α-C region of the kinase N-lobe. CDK18/CycY Recombinant Human Active Protein Kinase is an ortholog of CDK18 .

HY-E70674

CDK2/CycO Recombinant Human Active Protein Kinase	CDK	Cancer
CDK2 is a cyclin-dependent kinase involved in the control of the cell cycle. CDK2/CycO Recombinant Human Active Protein Kinase is an ortholog of CDK2 .

HY-E70851

Nuak2 Recombinant Human Active Protein Kinase	AMPK	Cancer
NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions .

HY-E70841

LIMK2 Recombinant Human Active Protein Kinase	LIM Kinase (LIMK)	Cancer
LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions .

HY-E70864

STK33 Recombinant Human Active Protein Kinase	CaMK	Metabolic Disease
STK33 is clearly related to the canonical kinases from the CAMK group. STK33 could be involved in the normal development of heart and other organs in embryonic and fetal stages. STK33 Recombinant Human Active Protein Kinase is a recombinant STK33 protein that can be used to study STK33-related functions .

HY-E70791

Biotin-AKT2 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT2 Recombinant Human Active Protein Kinase is obtained by expressing AKT2 proteins and is biotinylated .

HY-E70790

Biotin-AKT1 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT1 Recombinant Human Active Protein Kinase is obtained by expressing AKT1 proteins and is biotinylated .

HY-E70812

CaMK2β Recombinant Human Active Protein Kinase	CaMK	Cardiovascular Disease
CAMK2 is involved in the regulation of cellular processes in a variety of tissues. CaMK2β Recombinant Human Active Protein Kinase is obtained by expressing CaMK2β proteins .

Cat. No.	상품명

HY-L016

Protein Tyrosine Kinase Compound Library

1,578 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,578 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L009M

Kinase Inhibitor Library Mini

270 compounds

Kinases is a class of enzymes that adds chemicals called phosphates to other molecules, such as sugars or proteins. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes including cell division, metabolism, and signal transduction, with approximately 50% of cellular functions in humans being regulated by kinase activity. In drug discovery, kinases represent a major category of therapeutic targets, and kinase inhibitors constitute an important class of pharmaceuticals that block the activity of specific disease-associated enzymes, particularly in cancer and inflammatory disorders. Small molecule kinase inhibitors represent one of the fastest-growing drug categories, having received U.S. Food and Drug Administration (FDA) approval for both oncological and non-oncological indications. As of September 2023, over 70 FDA-approved small molecule kinase inhibitors are commercially available.

The MCE Kinase Inhibitor Library Mini contains 270 kinase inhibitors primarily targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.), and carbohydrate kinases. This collection includes 1-3 highly specific representative compounds per target, optimized for screening of kinase-related drug targets in pharmaceutical research.

HY-L009

Kinase Inhibitor Library

3,849 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,849 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L017

Stem Cell Signaling Compound Library

2,723 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 2,723 compounds that can be used for stem cell regulatory and signaling pathway research.

HY-LD004

DEL Covalent Library

14 million compounds

DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects.

Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding.

This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec

Cat. No.	상품명	Target	Research Area

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P5426

Abl protein tyrosine kinase substrate	Bcr-Abl	Others
Abl protein tyrosine kinase substrate is a biological active peptide. (Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.)

HY-P5430

DYRKtide	DYRK	Others
DYRKtide is a biological active peptide. (Dyrktide is designed as the optimal substrate sequence efficiently phosphorylated by DYRK1A, which is a dual-specificity protein kinase that is thought to be involved in brain development.)

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-P11358

IRW	Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism	Inflammation/Immunology
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation .

HY-P5429

DNA-PK Substrate	Peptides	Others
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P2668

Cdk5 Substrate	Peptides	Others
Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase)

HY-P5440

ERKtide	ERK	Others
ERKtide is a biological active peptide. (ERKtide is a peptide substrate for ERK2. Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by mitogenic stimuli.)

HY-P3930

PKI (5-24),amide IP20-amide	PKA	Neurological Disease
PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent *cAMP-dependent protein* kinase (PKA) (PKA) inhibitor with a K_i** of 2.3 nM .

HY-P5507

ERK2 Substrate Erktide	Peptides	Others
ERK2 Substrate (Erktide) is a biological active peptide. (Erktide is a peptide substrate for ERK2 (extracellular regulated protein kinase 2) whose activity is regulated by mitogenic stimuli.)

HY-P10042A

S6K Substrate acetate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-P5452

PKCd (8-17)	PKC	Others
PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)

HY-P5525

AC3-I, myristoylated Autocamtide-3 Derived Inhibitory Peptide	CaMK	Others
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-P5428

Cdc2 kinase substrate	CDK	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

HY-P10499

[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302)	CaMK	Others
[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) is a modified fragment of calcium/calmodulin-dependent protein kinase II that contains the active domain of CaMKII and has an alanine substitution at position 286. [Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) can be used to develop more potent CaMKII inhibitors .

HY-P3784

FKKSFKL-NH2	PKC	Metabolic Disease Inflammation/Immunology Cancer
FKKSFKL-NH2 is a protein kinase C-selective peptide. FKKSFKL-NH2 can be used for the research of various biochemical .

HY-P5454

RS Domain derived peptide	Peptides	Others
RS Domain derived peptide is a biological active peptide. (This peptide is a substrate for Clk/Sty and is phosphorylated by Clk/Sty protein kinase (Km=102 microM).)

HY-P1399

Pep2m, myristoylated Myr-Pep2m	PKC	Neurological Disease
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P1399A

Pep2m, myristoylated TFA Myr-Pep2m TFA	PKC	Neurological Disease
Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P3785

PKI(5-22)amide	PKA	Neurological Disease
PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors .

HY-P5466

S6(229-239)	Peptides	Others
S6(229-239) is a biological active peptide. (This is a synthetic peptide substrate for S6 kinase shown to be phosphorylated by protein kinase c with phosphorylation site identified at Ser235)

Cat. No.	상품명	Category	Target	Chemical Structure

HY-111355B

Cholesteryl sulfate sodium	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Sirtuin Endogenous Metabolite PKC AMPK DOCK
Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Cardiovascular Disease Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Rutaceae Plants Citrus Disease Research Fields Source Classification	Bacterial Antibiotic CaMK
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-N0281

Daphnetin Maximum Cited Publications 7 Publications Verification 7,8-Dihydroxycoumarin	Daphne Classification of Application Fields Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active **protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy** by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N2081

Skimmianine 3 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N0818

Chikusetsusaponin Iva 2 Publications Verification Calenduloside F	Triterpenes Classification of Application Fields Terpenoids Other Diseases Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields Source Classification	Keap1-Nrf2
Chikusetsusaponin IVa is an orally active **protein kinase activator. Chikusetsusaponin IVa binds to YAP with a K_D value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, IL-10, COX-2) expression, NO production, promotes ROS generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates Nrf2, JAK/STAT. Chikusetsusaponin Iva has anti-H9N2 AIV** and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects .

HY-111355

Cholesterol sulfate	Structural Classification Animals Steroids Source Classification	Endogenous Metabolite DOCK PKC AMPK Sirtuin
Cholesterol sulfate is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N1989

Bacoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Scrophulariaceae Metabolic Disease Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification	Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na ⁺/K ⁺-ATPase, Ca ²⁺-ATPase and Mg ²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .

HY-N0521R

(-)-Gallocatechin (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Reactive Oxygen Species (ROS)
(-)-Gallocatechin (Standard) is the analytical standard of (-)-Gallocatechin. This product is intended for research and analytical applications. (-)-Gallocatechin, an epimer of (-)-Epigallocatechin (EGC), is contained in various tea products. (-)-Gallocatechin has antioxidant activities. (-)-Gallocatechin is the main active component in green tea extract (HTP-GTE) responsible for its effect of improving age-related cognitive impairments involving protein kinase A (PKA) pathway .

HY-N2081R

Skimmianine (Standard)	Alkaloids Structural Classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Source Classification	Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N0281R

Daphnetin (Standard) 7,8-Dihydroxycoumarin (Standard)	Structural Classification Daphne Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-116529

Lamellarin E	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Lamellarin E is a biologically active marine alkaloid, while the Lamellarin series of alkaloids show potential cytotoxicity, topoisomerase I inhibition, protein kinase inhibition, multidrug resistance reversal, and anti-HIV-1 activity .

Cat. No.	상품명	Chemical Structure

HY-111355S

Cholesterol sulfate-d7 sodium

Cholesterol sulfate sodium-d₇ is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.

HY-175483S

TrkB activator-1

TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor)-Tropomyosin-related kinase B (TrkB)-CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression .

HY-112096S

eCF506-d5

eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .

HY-16305S1

Maribavir-d6 TFA
Maribavir-d6 TFA (1263W94-d6 TFA; BW1263W94-d6 TFA; GW257406X-d6 TFA) is a deuterium labeled Maribavir (HY-16305). Maribavir is an orally active antiviral agent for cytomegalovirus (CMV) through inhibition of protein kinase UL97 and the following CMV DNA replication .

HY-W751181

O-Desmethyl midostaurin-13C6

O-Desmethyl midostaurin- ¹³C₆ (CGP62221- ¹³C₆; O-Desmethyl PKC412- ¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-101570G

Nedisertib Peposertib; M3814	DNA-PK BCRP	Cancer
Nedisertib (GMP) (Peposertib (GMP)) is Nedisertib (HY-101570) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nedisertib is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .

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