MEK2 Protein, Human (sf9, GST)

MEK2, a pivotal kinase in cellular signaling, catalyzes the simultaneous phosphorylation of a threonine and a tyrosine residue within the Thr-Glu-Tyr sequence of MAP kinases. This enzymatic activity results in the activation of ERK1 and ERK2 MAP kinases, contributing to the intricate network of cellular responses. MEK2's role extends to the activation of BRAF, a process regulated by its interaction with KSR1 or KSR2. Binding to KSR1 or KSR2 facilitates the release of inhibitory intramolecular interactions within KSR1 or KSR2, promoting the dimerization of KSR1 or KSR2 with BRAF and subsequent BRAF activation. This mechanism highlights MEK2's significance in orchestrating signaling cascades critical for cellular functions. MEK2 Protein, Human (sf9, GST) is the recombinant human-derived MEK2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MEK2 Protein, Human (sf9, GST) is 400 a.a., with molecular weight of ~66 kDa.

MEK2, a pivotal kinase in cellular signaling, catalyzes the simultaneous phosphorylation of a threonine and a tyrosine residue within the Thr-Glu-Tyr sequence of MAP kinases. This enzymatic activity results in the activation of ERK1 and ERK2 MAP kinases, contributing to the intricate network of cellular responses. MEK2's role extends to the activation of BRAF, a process regulated by its interaction with KSR1 or KSR2. Binding to KSR1 or KSR2 facilitates the release of inhibitory intramolecular interactions within KSR1 or KSR2, promoting the dimerization of KSR1 or KSR2 with BRAF and subsequent BRAF activation. This mechanism highlights MEK2's significance in orchestrating signaling cascades critical for cellular functions.

Human

Sf9 insect cells

N-GST

P36507 (M1-V400)

5605  [NCBI]

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.