FES Protein, Human (Active)
FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES, Human (Active) is the recombinant human-derived FES protein, expressed by E. coli, with N-Avi labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES, Human (Active) is the recombinant human-derived FES protein, expressed by E. coli, with N-Avi labeled tag.
Background
FES, a tyrosine-protein kinase, functions downstream of cell surface receptors, contributing to the regulation of various cellular processes, including the actin cytoskeleton dynamics, microtubule assembly, cell attachment, and cell spreading. It plays a crucial role in FCER1-mediated signaling in mast cells, influencing mast cell degranulation, and acts downstream of the KIT receptor. Additionally, FES is involved in cell differentiation, promoting neurite outgrowth in response to NGF signaling. It contributes to cell scattering and migration triggered by HGF-induced activation of EZR. FES phosphorylates key proteins such as BCR, leading to the down-regulation of BCR kinase activity, as well as HCLS1/HS1, PECAM1, STAT3, and TRIM28, underscoring its diverse regulatory functions in cellular signaling pathways.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P07332-1 (I448-R822)
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Gene ID2242
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Molecular Construction
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N-term
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(I448-R822)
Accession # P07332-1 -
C-term
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Protein Length
Partial
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Synonyms
FES; Proto-Oncogene C-Fes; FES Proto-Oncogene, Tyrosine Kinase; Proto-Oncogene C-Fps; FPS; C-Fes/Fps Protein; Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog; P93c-Fes; Feline Sarcoma/Fujinami Av
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AA Sequence
IPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipped with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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