MAP4K6 Protein, Human (Active, sf9, GST)

MAP4K6 protein is a key serine/threonine kinase that negatively regulates Ras-related Rap2-mediated signaling, affecting neuronal structure and AMPA receptor trafficking. Its importance is underlined by its important role in regulating synaptic density, dendritic complexity, and surface AMPA receptor expression in hippocampal neurons. MAP4K6 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K6 protein, expressed by sf9 insect cells , with N-GST labeled tag.

MAP4K6, a serine/threonine kinase, serves as a crucial negative regulator in Ras-related Rap2-mediated signal transduction, exerting control over neuronal structure and AMPA receptor trafficking. Its significance is underscored by its essential role in regulating synaptic density, dendrite complexity, and surface AMPA receptor expression in hippocampal neurons. MAP4K6 exhibits the capacity to activate the JNK and MAPK14/p38 pathways, mediating stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. It phosphorylates TANC1 upon stimulation by RAP2A, as well as MBP and SMAD1. Furthermore, MAP4K6 plays a pivotal role in the negative selection of thymocytes, potentially by facilitating the coupling of NCK1 to the activation of JNK1. Notably, isoform 4 of MAP4K6 can independently activate the JNK pathway. In addition to its diverse roles in cellular processes, MAP4K6 is intricately involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion, and cell migration, highlighting its multifaceted impact on cellular dynamics.

Human

Sf9 insect cells

N-GST

Q8N4C8 (M1-G314)

50488

Partial

MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.