RPS6KA4 Protein, Human (Active, sf9, His, GST)
RPS6KA4 Protein, Human (sf9, His, GST) is the recombinant human-derived RPS6KA4, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
RPS6KA4 Protein, Human (sf9, His, GST) is the recombinant human-derived RPS6KA4, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. ,
Background
RPS6KA4 is a serine/threonine-protein kinase involved in key biological processes. It phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli (e.g., UV-C irradiation, EGF, and anisomycin) and regulates RELA transcriptional activity, particularly in TNF signaling. This kinase also phosphorylates histone H3 at Ser-10 (and potentially Ser-28), activating transcription of immediate early genes like c-fos/FOS and c-jun/JUN. In LPS-stimulated macrophages, it limits pro-inflammatory cytokine production downstream of TLR4, likely by inducing DUSP1 and anti-inflammatory IL10 expression. by similar: Additional studies indicate its role in phosphorylating HMGN1/HMG14 to modulate chromatin structure.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His;N-GST
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Accession
O75676-1 (M1-S772)
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Gene ID8986
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Protein Length
Full Length of Isoform-1
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Synonyms
RPS6KA4; S6K-Alpha-4; Ribosomal Protein S6 Kinase A4; Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 4; MSK2; Ribosomal Protein S6 Kinase, 90kD, Polypeptide 4; RSK-B; Mitogen- And Stress-Activated Protein Kinase 2; Nuclear Mitogen- And Stress-Activated P
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AA Sequence
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
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Predicted Molecular Mass
113.3 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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