RSK3 Protein, Human (sf9, GST)

RSK3, a kinase downstream of ERK signaling, crucially mediates mitogenic and stress-induced transcription factor activation. It regulates translation, impacting proliferation, survival, and differentiation. In epithelial ovarian cancer cells, RSK3 may act as a tumor suppressor, highlighting its diverse roles in cellular homeostasis and potential implications in cancer biology. RSK3 Protein, Human (sf9, GST) is the recombinant human-derived RSK3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of RSK3 Protein, Human (sf9, GST) is 733 a.a., with molecular weight of ~110 kDa.

RSK3, a serine/threonine-protein kinase, operates downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling, playing a crucial role in mediating mitogenic and stress-induced activation of transcription factors. Its involvement extends to the regulation of translation and mediation of cellular processes such as proliferation, survival, and differentiation. Notably, in epithelial ovarian cancer cells, RSK3 may function as a tumor suppressor, further emphasizing its diverse roles in cellular homeostasis and potential implications in cancer biology.

Human

Sf9 insect cells

N-GST

Q15349 (M1-L733)

6196  [NCBI]

Approximately 110 kDa

Greater than 84% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.