CIT Protein, Human (Active, sf9)
CIT Protein, Human (sf9) is the recombinant human-derived CIT, expressed by Sf9 insect cells , with tag Free labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CIT Protein, Human (sf9) is the recombinant human-derived CIT, expressed by Sf9 insect cells , with tag Free labeled tag.
Background
CIT is a protein that plays a crucial role in cytokinesis, facilitating the localization of KIF14 to the central spindle and midbody. As a putative RHO/RAC effector, it binds to the GTP-bound forms of RHO and RAC1 and may exhibit tighter binding specificity for p21 in vivo. CIT also displays serine/threonine protein kinase activity and phosphorylates MYL9/MLC2. It is essential for regulating cytokinesis and the development of the central nervous system. by similar: CIT's functions are closely associated with cell division and signaling, particularly through the RHO/RAC pathway.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
O14578-1 (M1-Q499)
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Gene ID11113
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Protein Length
Partial
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Synonyms
CIT; Citron (Rho-Interacting, Serine/Threonine Kinase 21); Citron Rho-Interacting Serine/Threonine Kinase; Serine/Threonine-Protein Kinase 21; STK21; Citron Rho-Interacting Kinase; CRIK; Serine/Threonine Kinase 21; KIAA0949; Non-Specific Serine/Threonine
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AA Sequence
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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