CIT/CRIK
Citron kinase (CIT), often abbreviated CRIK, is the largest protein in the DMPK group and a central regulator of cytokinesis. Activated by RHOA rather than CDC42, it localises to the cleavage furrow and midbody, where it phosphorylates KIF14, KIF20A and components of the centralspindlin complex to coordinate the timing of abscission. Alternative splicing yields a long kinase-bearing CIT-K isoform enriched in brain and testis and a shorter CIT-N variant; loss of CIT-K causes primary microcephaly with simplified gyral pattern in humans, underscoring its role in neural progenitor division. Recombinant CIT is applied to cytokinesis reconstitution, midbody signalling studies and screening against this RHOA effector.
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CIT/CRIK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
