PRKX Protein, Human (Active, sf9, GST)
PRKX is an important serine/threonine kinase that mediates cAMP signaling and phosphorylates targets such as CREB, SMAD6, and PKD1. It regulates myeloid cell differentiation through SMAD6 phosphorylation, promotes nephrogenesis by enhancing renal epithelial cell migration and tubulogenesis, and actively promotes angiogenesis by affecting endothelial cell proliferation and migration. PRKX Protein, Human (sf9, GST) is the recombinant human-derived PRKX protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
PRKX is an important serine/threonine kinase that mediates cAMP signaling and phosphorylates targets such as CREB, SMAD6, and PKD1. It regulates myeloid cell differentiation through SMAD6 phosphorylation, promotes nephrogenesis by enhancing renal epithelial cell migration and tubulogenesis, and actively promotes angiogenesis by affecting endothelial cell proliferation and migration. PRKX Protein, Human (sf9, GST) is the recombinant human-derived PRKX protein, expressed by sf9 insect cells , with N-GST labeled tag.
Background
PRKX, a serine/threonine protein kinase, operates as a key mediator of cAMP signaling within cells. Its functionality is rooted in phosphorylating downstream targets, potentially including CREB, SMAD6, and PKD1, thereby orchestrating diverse roles in cellular differentiation and epithelial morphogenesis. PRKX plays a pivotal role in regulating myeloid cell differentiation through the phosphorylation of SMAD6 and contributes to nephrogenesis by stimulating the migration and tubulogenesis of renal epithelial cells. Furthermore, PRKX is actively involved in angiogenesis, exerting its influence by promoting endothelial cell proliferation, migration, and the formation of vascular-like structures. The multifaceted functions of PRKX underscore its significance in orchestrating intricate cellular processes essential for development and tissue morphogenesis.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST
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Accession
P51817 (M1-F358)
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Gene ID5613
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Molecular Construction
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N-term
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GST
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PRKX (M1-F358)
Accession # P51817 -
C-term
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Protein Length
Full Length
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Synonyms
PRKX; Serine/Threonine-Protein Kinase PRKX; Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit; Protein Kinase PKX1; PKX1; Protein Kinase X; Protein Kinase X-Linked; PrKX; CAMP-Dependent Protein Kinase Catalytic Subunit PRKX
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AA Sequence
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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