PRKX Protein, Human (Active, sf9, GST)

PRKX is an important serine/threonine kinase that mediates cAMP signaling and phosphorylates targets such as CREB, SMAD6, and PKD1. It regulates myeloid cell differentiation through SMAD6 phosphorylation, promotes nephrogenesis by enhancing renal epithelial cell migration and tubulogenesis, and actively promotes angiogenesis by affecting endothelial cell proliferation and migration. PRKX Protein, Human (sf9, GST) is the recombinant human-derived PRKX protein, expressed by sf9 insect cells , with N-GST labeled tag.

PRKX, a serine/threonine protein kinase, operates as a key mediator of cAMP signaling within cells. Its functionality is rooted in phosphorylating downstream targets, potentially including CREB, SMAD6, and PKD1, thereby orchestrating diverse roles in cellular differentiation and epithelial morphogenesis. PRKX plays a pivotal role in regulating myeloid cell differentiation through the phosphorylation of SMAD6 and contributes to nephrogenesis by stimulating the migration and tubulogenesis of renal epithelial cells. Furthermore, PRKX is actively involved in angiogenesis, exerting its influence by promoting endothelial cell proliferation, migration, and the formation of vascular-like structures. The multifaceted functions of PRKX underscore its significance in orchestrating intricate cellular processes essential for development and tissue morphogenesis.

Human

Sf9 insect cells

N-GST

P51817 (M1-F358)

5613

Full Length

MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.