LTK Protein, Human (Active, sf9, GST)

LTK protein, a tyrosine-protein kinase activated by ALKAL1 or ALKAL2 ligands, transduces signals, initiating the MAPK pathway upon ligand binding. It phosphorylates mainly the first tyrosine in the Y-x-x-x-Y-Y motif, with roles in promoting neurite outgrowth, cell survival, and regulating the secretory pathway, impacting ERESs and ER to Golgi transport. LTK Protein, Human (sf9, GST) is the recombinant human-derived LTK protein, expressed by sf9 insect cells , with N-GST labeled tag.

LTK protein, possessing tyrosine-protein kinase activity, is activated by ALKAL1 or ALKAL2 ligands, transducing extracellular signals into intracellular responses. Upon ligand binding at the cell surface, the receptor undergoes tyrosine kinase activation, leading to the initiation of the mitogen-activated protein kinase (MAPK) pathway. Notably, LTK phosphorylates predominantly at the first tyrosine of the Y-x-x-x-Y-Y motif. While the precise function of LTK remains unclear, chimeric protein studies suggest its capacity to promote growth, specifically neurite outgrowth, and cell survival. Additionally, LTK is implicated in the regulation of the secretory pathway, influencing endoplasmic reticulum export sites (ERESs) and ER to Golgi transport.

Human

Sf9 insect cells

N-GST

P29376 (K450-S864)

4058

Cytoplasmic Domain

KQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.