LTK Protein, Human (Active, sf9, GST)
LTK protein, a tyrosine-protein kinase activated by ALKAL1 or ALKAL2 ligands, transduces signals, initiating the MAPK pathway upon ligand binding. It phosphorylates mainly the first tyrosine in the Y-x-x-x-Y-Y motif, with roles in promoting neurite outgrowth, cell survival, and regulating the secretory pathway, impacting ERESs and ER to Golgi transport. LTK Protein, Human (sf9, GST) is the recombinant human-derived LTK protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
LTK protein, a tyrosine-protein kinase activated by ALKAL1 or ALKAL2 ligands, transduces signals, initiating the MAPK pathway upon ligand binding. It phosphorylates mainly the first tyrosine in the Y-x-x-x-Y-Y motif, with roles in promoting neurite outgrowth, cell survival, and regulating the secretory pathway, impacting ERESs and ER to Golgi transport. LTK Protein, Human (sf9, GST) is the recombinant human-derived LTK protein, expressed by sf9 insect cells , with N-GST labeled tag.
Background
LTK protein, possessing tyrosine-protein kinase activity, is activated by ALKAL1 or ALKAL2 ligands, transducing extracellular signals into intracellular responses. Upon ligand binding at the cell surface, the receptor undergoes tyrosine kinase activation, leading to the initiation of the mitogen-activated protein kinase (MAPK) pathway. Notably, LTK phosphorylates predominantly at the first tyrosine of the Y-x-x-x-Y-Y motif. While the precise function of LTK remains unclear, chimeric protein studies suggest its capacity to promote growth, specifically neurite outgrowth, and cell survival. Additionally, LTK is implicated in the regulation of the secretory pathway, influencing endoplasmic reticulum export sites (ERESs) and ER to Golgi transport.
Technical Parameters
-
Species Human
-
Source Sf9 insect cells
-
Tag N-GST
-
Accession
P29376 (K450-S864)
-
Gene ID4058
-
Molecular Construction
-
N-term
-
GST
-
LTK (K450-S864)
Accession # P29376 -
C-term
-
-
Protein Length
Cytoplasmic Domain
-
Synonyms
LTK; Protein Tyrosine Kinase 1; Leukocyte Receptor Tyrosine Kinase; Receptor Protein-Tyrosine Kinase; TYK1; Tyrosine-Protein Kinase Receptor; Leukocyte Tyrosine Kinase Receptor; Leukocyte Tyrosine Kinase
-
AA Sequence
KQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
