ABL1 Protein, Human (Active, sf9, GST)

ABL1, a non-receptor tyrosine-protein kinase, orchestrates diverse cellular processes crucial for growth and survival. Its multifaceted roles include coordinating cytoskeleton remodeling in response to extracellular cues, regulating cell motility, and influencing receptor endocytosis. ABL1's impact extends to autophagy, DNA damage response, and apoptosis, where it phosphorylates key substrates involved in these pathways. Notably, it modulates actin dynamics by phosphorylating proteins like WASF3 and ANXA1, influencing processes such as lamellipodia formation and cell migration. A critical player in cell adhesion and motility, ABL1 phosphorylates regulators like BCAR1 and CRK. Furthermore, it engages in the regulation of receptor tyrosine kinases, including the facilitation of EGFR endocytosis. ABL1's reach extends to mitochondrial function during oxidative stress, where it mediates dysfunction and cell death. Additionally, it translocates to the nucleus, contributing to DNA damage response, apoptosis, and the regulation of T-cell differentiation. ABL1's extensive substrate repertoire encompasses proteins involved in DNA repair and apoptosis, showcasing its central role in cellular homeostasis and response to external stimuli.