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  3. PTC299

PTC299 

Cat. No.: HY-124593
Handling Instructions

PTC299 is a dihydroorotate dehydrogenase (DHODH) inhibitor, has broad and potent activity against hematological cancer cells. PTC299 is also an orally bioavailable VEGF inhibitor, acts through posttranscriptional regulation of VEGF mRNA under conditions of cellular stress.

For research use only. We do not sell to patients.

PTC299 Chemical Structure

PTC299 Chemical Structure

CAS No. : 1256565-36-2

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Description

PTC299 is a dihydroorotate dehydrogenase (DHODH) inhibitor, has broad and potent activity against hematological cancer cells[1]. PTC299 is also an orally bioavailable VEGF inhibitor, acts through posttranscriptional regulation of VEGF mRNA under conditions of cellular stress[2].

IC50 & Target

Dihydroorotate dehydrogenase[1], VEGF[2]

In Vitro

PTC299 inhibits hypoxia-induced VEGFA protein production in HeLa cells with an EC50 of 1.64 ± 0.83 nM[1].
PTC299 is the most potent inhibitor with an IC50 of about 1 nM, over 10 to 1000-fold more potent than Brequinar, Vidofludimus or Teriflunomide in leukemia cells[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

467.34

Formula

C₂₅H₂₀Cl₂N₂O₃

CAS No.

1256565-36-2

SMILES

O=C(N([[email protected]]1C2=CC=C(OC)C=C2)CCC3=C1NC4=C3C=C(Cl)C=C4)OC5=CC=C(Cl)C=C5

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
PTC299
Cat. No.:
HY-124593
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PTC299

Cat. No.: HY-124593