PAK6 Protein, Human (Active, His)
PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag.
PAK6, a serine/threonine protein kinase, serves as a regulator of gene transcription, with its kinase activity triggered by various effectors, including AR or MAP2K6/MAPKK6. Notably, it phosphorylates the DNA-binding domain of the androgen receptor/AR, hindering AR-mediated transcription, and also inhibits ESR1-mediated transcription. PAK6's involvement in cytoskeleton regulation is suggested by its interaction with IQGAP1. Additionally, PAK6 demonstrates a potential role in cell survival by protecting cells from apoptosis through the phosphorylation of BAD. This multifaceted kinase exhibits a regulatory impact on key cellular processes, showcasing its significance in transcriptional control and cytoskeletal dynamics.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q9NQU5 (G383-Y674)
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Gene ID106821730
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Molecular Construction
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N-term
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6*His
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PAK6 (G383-Y674)
Accession # Q9NQU5 -
C-term
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Protein Length
Partial
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Synonyms
PAK6; P21(CDKN1A)-Activated Kinase 6; P21 (RAC1) Activated Kinase 6; Non-Specific Serine/Threonine Protein Kinase; PAK5; P21-Activated Kinase 6; P21 Protein (Cdc42/Rac)-Activated Kinase 6; PAK-6; Serine/Threonine-Protein Kinase PAK 6; PAK-5
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AA Sequence
GVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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