PKN2 Protein, Human (Active, sf9, His, GST)
PKN2 Protein, Human (sf9, His, GST) is the recombinant human-derived PKN2, expressed by Sf9 insect cells , with His, GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
PKN2 Protein, Human (sf9, His, GST) is the recombinant human-derived PKN2, expressed by Sf9 insect cells , with His, GST labeled tag. ,
Background
PRK2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein involved in specific cellular signal transduction responses. It regulates cell cycle progression, actin cytoskeleton assembly, cell migration, adhesion, tumor invasion, and transcriptional activation. PRK2 phosphorylates CTTN in hyaluronan-induced astrocytes, reducing CTTN's F-actin binding capacity, and HDAC5 to impair its nuclear import. As a direct RhoA target, it mediates primordial-to-apical junction maturation in bronchial epithelial cells. It facilitates G2/M phase progression and cytokinesis abscission via ECT2, stimulates FYN kinase activity for keratinocyte adhesion, and modulates bladder epithelial cell migration direction/speed during tumor invasion. PRK2 inhibits Akt pro-survival signaling, mediates Rho-induced transcription via c-fos SRF, and negatively regulates ciliogenesis. by similar: During microbial infection, it phosphorylates HCV NS5B to enhance HCV RNA replication.
Technical Parameters
-
Species Human
-
Source Sf9 insect cells
-
Tag His;GST
-
Accession
Q16513-1 (A2-C984)
-
Gene ID5586
-
Protein Length
Full Length of Isoform-1
-
Synonyms
PKN2; Cardiolipin-Activated Protein Kinase Pak2; Prev. PRKCL2; Protein-Kinase C-Related Kinase 2; PRK2; PKN Gamma; Protein Kinase C-Like 2; PKN2 Protein; Pak-2; PRO2042; STK7; PAK2; Protein Kinase N2; Serine/Threonine-Protein Kinase N2
-
AA Sequence
ASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC
-
Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
