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Art. -Nr.: HY-106603

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Sulofenur

Name: Sulofenur
Brand: MedChemExpress
SKU: HY-106603
Availability: PreOrder

(Synonyms: Diarylsulfonylurea; LY186641)

Sulofenur (LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models.

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CAS. Nr.: 110311-27-8
Formel: C₁₆H₁₅ClN₂O₃S
Molecular Weight:350.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Sulofenur Chemical Structure

CAS. Nr.: 110311-27-8

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: Sulofenur	Anticancer activity against human A549 cells by MTT assay Anticancer activity against human A549 cells by MTT assay	[PMID: 21570750]
A549	IC₅₀	11.34 μM Compound: LY-186641	In vitro cytotoxic activity against human lung carcinoma A549 cell line In vitro cytotoxic activity against human lung carcinoma A549 cell line	10.1016/0960-894X(96)00463-5
A549	IC₅₀	36.43 μM Compound: 2	Cytotoxicity against human lung carcinoma A549 cell line using MTT assay Cytotoxicity against human lung carcinoma A549 cell line using MTT assay	[PMID: 9873387]
CCRF-CEM	IC₅₀	11.2 μg/mL Compound: 104 (LY-186641)	Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth	[PMID: 2391684]
CCRF-CEM	IC₅₀	11.2 μg/mL Compound: Sulofenur	In vitro cytotoxicity against CCRF-CEM cells In vitro cytotoxicity against CCRF-CEM cells	[PMID: 9083492]
CCRF-CEM	IC₅₀	32 μM Compound: Sulofenur	Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line	[PMID: 10476861]
COLO 205	IC₅₀	23.06 μM Compound: Sulofenur	Anticancer activity against human COLO205 cells by MTT assay Anticancer activity against human COLO205 cells by MTT assay	[PMID: 21570750]
K562	IC₅₀	19.2 μM Compound: Sulofenur	Anticancer activity against human K562 cells by MTT assay Anticancer activity against human K562 cells by MTT assay	[PMID: 21570750]
K562	IC₅₀	50.08 μM Compound: 2	Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay	[PMID: 9873387]
P388D1	IC₅₀	>100 μM Compound: Sulofenur	Anticancer activity against mouse P388D1 cells by MTT assay Anticancer activity against mouse P388D1 cells by MTT assay	[PMID: 21570750]
SK-MEL-2	IC₅₀	12.91 μM Compound: LY-186641	In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line	10.1016/0960-894X(96)00463-5
SK-OV-3	IC₅₀	222.9 μM Compound: 2	Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay	[PMID: 9873387]
SK-OV-3	IC₅₀	78.2 μM Compound: Sulofenur	Anticancer activity against human SKOV3 cells by MTT assay Anticancer activity against human SKOV3 cells by MTT assay	[PMID: 21570750]

Chemical Information

CAS. Nr. 110311-27-8
Molecular Weight 350.82
Formel C₁₆H₁₅ClN₂O₃S
SMILES

O=S(C1=CC2=C(CCC2)C=C1)(NC(NC3=CC=C(Cl)C=C3)=O)=O
Synonyms

Diarylsulfonylurea; LY186641
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gu H, et al. H-ras transfection of the rat kidney cell line NRK-52E results in increased induction of c-fos, c-jun and hsp70 following sulofenur treatment. Cancer Lett. 1996 Sep 10;106(2):199-205. [Content Brief]

[2]. Brown TD, et al. Phase I trial of sulofenur (LY186641) given orally on a daily x 21 schedule. Anticancer Drugs. 1994 Apr;5(2):151-9. [Content Brief]

[3]. Ehlhardt WJ, et al. Pharmacokinetics of the anticancer agent sulofenur in mice, rats, monkeys, and dogs. J Pharm Sci. 1993 Jul;82(7):683-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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Sulofenur

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