2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Sulofenur

Sulofenur  (Synonyms: Diarylsulfonylurea; LY186641)

Cat. No.: HY-106603
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Sulofenur (LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models.

For research use only. We do not sell to patients.

Sulofenur

Sulofenur Chemical Structure

CAS No. : 110311-27-8

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Sulofenur Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Sulofenur (LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models[1][2][3].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
11.34 μM
Compound: LY-186641
In vitro cytotoxic activity against human lung carcinoma A549 cell line
In vitro cytotoxic activity against human lung carcinoma A549 cell line
10.1016/0960-894X(96)00463-5
A549 IC50
36.43 μM
Compound: 2
Cytotoxicity against human lung carcinoma A549 cell line using MTT assay
Cytotoxicity against human lung carcinoma A549 cell line using MTT assay
[PMID: 9873387]
A549 IC50
> 20 μM
Compound: Sulofenur
Anticancer activity against human A549 cells by MTT assay
Anticancer activity against human A549 cells by MTT assay
[PMID: 21570750]
CCRF-CEM IC50
11.2 μg/mL
Compound: 104 (LY-186641)
Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
[PMID: 2391684]
CCRF-CEM IC50
11.2 μg/mL
Compound: Sulofenur
In vitro cytotoxicity against CCRF-CEM cells
In vitro cytotoxicity against CCRF-CEM cells
[PMID: 9083492]
CCRF-CEM IC50
32 μM
Compound: Sulofenur
Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line
Cytotoxicity against CCRF-CEM lymphocytic leukemia cell line
[PMID: 10476861]
COLO 205 IC50
23.06 μM
Compound: Sulofenur
Anticancer activity against human COLO205 cells by MTT assay
Anticancer activity against human COLO205 cells by MTT assay
[PMID: 21570750]
K562 IC50
19.2 μM
Compound: Sulofenur
Anticancer activity against human K562 cells by MTT assay
Anticancer activity against human K562 cells by MTT assay
[PMID: 21570750]
K562 IC50
50.08 μM
Compound: 2
Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay
Cytotoxicity against human chronic myelogenous leukemia (K562) cell line using MTT assay
[PMID: 9873387]
P388D1 IC50
> 100 μM
Compound: Sulofenur
Anticancer activity against mouse P388D1 cells by MTT assay
Anticancer activity against mouse P388D1 cells by MTT assay
[PMID: 21570750]
SK-MEL-2 IC50
12.91 μM
Compound: LY-186641
In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line
In vitro cytotoxic activity against human melanoma SK-MEL-2 cell line
10.1016/0960-894X(96)00463-5
SK-OV-3 IC50
222.9 μM
Compound: 2
Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay
Cytotoxicity against human ovarian adenocarcinoma (SK-OV-3) cell line using MTT assay
[PMID: 9873387]
SK-OV-3 IC50
78.2 μM
Compound: Sulofenur
Anticancer activity against human SKOV3 cells by MTT assay
Anticancer activity against human SKOV3 cells by MTT assay
[PMID: 21570750]
Molecular Weight

350.82

Formula

C16H15ClN2O3S
CAS No.
SMILES

O=S(C1=CC2=C(CCC2)C=C1)(NC(NC3=CC=C(Cl)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sulofenur Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulofenur110311-27-8Diarylsulfonylurea LY186641LY186641LY 186641LY-186641Calcium ChannelCa2+ channelsCa channelsCytosolic Ca2+H-rasKidney cellsProtein kinasesc-fosc-junhsp70Inhibitorinhibitorinhibit

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