110311-27-8
Chemical Structure
Sulofenur
Synonym(s): Diarylsulfonylurea; LY186641
- CAS No.: 110311-27-8
- Formula:C16H15ClN2O3S
- Molecular Weight:350.82
IUPAC Name: N-((4-chlorophenyl)carbamoyl)-2,3-dihydro-1H-indene-5-sulfonamide
InChIKey: JQJSFAJISYZPER-UHFFFAOYSA-N
SMILES: O=S(C1=CC2=C(CCC2)C=C1)(NC(NC3=CC=C(Cl)C=C3)=O)=O
Biological Activity: Sulofenur (LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models[1][2][3].
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Sulofenur | Sulofenur (LY186641) is an orally active anti-tumor agent. Sulofenur induces gene expression through calcium ion-dependent pathways and some protein kinase-independent pathways, and its effect is particularly enhanced in H-ras mutant cells. Sulofenur exhibits significant activity in mouse solid tumor models and human tumor xenograft models. | |||||||||||||||||||||
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References
- [1]. Gu H, et al. H-ras transfection of the rat kidney cell line NRK-52E results in increased induction of c-fos, c-jun and hsp70 following sulofenur treatment. Cancer Lett. 1996 Sep 10;106(2):199-205. [Content Brief]
- [2]. Brown TD, et al. Phase I trial of sulofenur (LY186641) given orally on a daily x 21 schedule. Anticancer Drugs. 1994 Apr;5(2):151-9. [Content Brief]
- [3]. Ehlhardt WJ, et al. Pharmacokinetics of the anticancer agent sulofenur in mice, rats, monkeys, and dogs. J Pharm Sci. 1993 Jul;82(7):683-8. [Content Brief]
