2. PI3K/Akt/mTOR Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. PI3K mTOR Akt HSP
  4. CC-11

CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer.

For research use only. We do not sell to patients.

CC-11

CC-11 Chemical Structure

CAS No. : 3079942-94-9

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CC-11 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer[1].

IC50 & Target[1]

HSP90

15 nM (IC50)

PI3Kα

0.54 nM (IC50)

Molecular Weight

1077.12

Formula

C52H54F2N12O10S
CAS No.
SMILES

CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CC-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC-113079942-94-9CC11CC 11PI3KmTORAktHSPPhosphoinositide 3-kinaseMammalian target of RapamycinPKBProtein kinase BHeat shock proteinsPI3K/mTOR-HSP90 conjugateSMDCcolorectal cancertargeted therapyHSP90 inhibitorPI3K inhibitorsmall molecule drug conjugatestructure-activity relationshipantitumor activityInhibitorinhibitorinhibit

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