ATR-IN-32
ATR-IN-32 is an orally active ATR inhibitor. ATR-IN-32 potently inhibits the proliferation of MIA PaCa-2 cells. ATR-IN-32 exerts significant tumor growth inhibition in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 can be used for the study of cancers mediated by ATR protein kinase, such as colorectal cancer, pancreatic cancer.
For research use only. We do not sell to patients.
- CAS No.: 2902715-97-1
- Formula: C22H24N6O2
- Molecular Weight:404.46
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ATR-IN-32 (Compound 29) (72 h) exhibits potent antiproliferative activity against MIA PaCa-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | T1/2 | AUC0-last | F | Vdss | CL |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 10 mg/kg | p.o. | 1716.67 ng/mL | 0.5 h | 0.78 h | 3302.52 ng·h/mL | 34.46 % | / | / |
| Mice[1] | 2 mg/kg | i.v. | / | / | 0.67 h | 1915.54 ng·h/mL | / | 0.58 L/kg | 17.4 mL/min/kg |
| Rat[1] | 1 mg/kg | i.v. | / | / | 1.71 h | 669.25 ng·h/mL | / | 3.0 L/kg | 24.90 mL/min/kg |
| Rat[1] | 10 mg/kg | p.o. | 1546.67 ng/mL | 1 h | 2.85 h | 8029.91 ng·h/mL | 119.98 % | / | / |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LOVO cells or HT-29 cells (1×107) were subcutaneously implanted into the left back of nude mice[1]
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Dosage:20 mg/kg
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Administration:p.o., 3 days on/4 days off per week for 21 days
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Result:Exerted significant intracranial anti-tumor efficacy with TGI of 83.2% in mice bearing LOVO xenografts.
Exerted significant intracranial anti-tumor efficacy with TGI of 49.9% in mice bearing LOVO xenografts.
Chemical Information
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CAS No. 2902715-97-1
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Appearance Solid
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Molecular Weight 404.46
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Formula C22H24N6O2
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Color Off-white to light brown
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SMILES
N#CC1(CCOCC1)C2=CC(N3[C@@H](COCC3)C)=NC4=C2C=CN=C4C5=NNC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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