2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATR-IN-32

ATR-IN-32 is an orally active ATR inhibitor. ATR-IN-32 potently inhibits the proliferation of MIA PaCa-2 cells. ATR-IN-32 exerts significant tumor growth inhibition in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 can be used for the study of cancers mediated by ATR protein kinase, such as colorectal cancer, pancreatic cancer.

For research use only. We do not sell to patients.

ATR-IN-32

ATR-IN-32 Chemical Structure

CAS No. : 2902715-97-1

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ATR-IN-32 Related Antibodies

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Description

ATR-IN-32 is an orally active ATR inhibitor. ATR-IN-32 potently inhibits the proliferation of MIA PaCa-2 cells. ATR-IN-32 exerts significant tumor growth inhibition in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 can be used for the study of cancers mediated by ATR protein kinase, such as colorectal cancer, pancreatic cancer[1].

In Vitro

ATR-IN-32 (Compound 29) (72 h) exhibits potent antiproliferative activity against MIA PaCa-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATR-IN-32 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax T1/2 AUC0-last F Vdss CL
Mice[1] 10 mg/kg p.o. 1716.67 ng/mL 0.5 h 0.78 h 3302.52 ng·h/mL 34.46 % / /
Mice[1] 2 mg/kg i.v. / / 0.67 h 1915.54 ng·h/mL / 0.58 L/kg 17.4 mL/min/kg
Rat[1] 1 mg/kg i.v. / / 1.71 h 669.25 ng·h/mL / 3.0 L/kg 24.90 mL/min/kg
Rat[1] 10 mg/kg p.o. 1546.67 ng/mL 1 h 2.85 h 8029.91 ng·h/mL 119.98 % / /
In Vivo

ATR-IN-32 (Compound 29) (20 mg/kg, p.o., 3 days on/4 days off per week for 21 days) exerts significant intracranial anti-tumor efficacy in nude mice bearing LOVO and HT-29 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LOVO cells or HT-29 cells (1×107) were subcutaneously implanted into the left back of nude mice[1]
Dosage: 20 mg/kg
Administration: p.o., 3 days on/4 days off per week for 21 days
Result: Exerted significant intracranial anti-tumor efficacy with TGI of 83.2% in mice bearing LOVO xenografts.
Exerted significant intracranial anti-tumor efficacy with TGI of 49.9% in mice bearing LOVO xenografts.
Molecular Weight

404.46

Formula

C22H24N6O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

N#CC1(CCOCC1)C2=CC(N3[C@@H](COCC3)C)=NC4=C2C=CN=C4C5=NNC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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ATR-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-322902715-97-1ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedcolorectal cancerpancreatic cancerATRLOVOHT-29MIA PaCa-2 cellsInhibitorinhibitorinhibit

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