FES Protein, Human (Active, His)
FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES Protein, Human (His) is the recombinant human-derived FES, expressed by E. coli, with His labeled tag. The total length of FES Protein, Human (His) is 375 a.a..
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES Protein, Human (His) is the recombinant human-derived FES, expressed by E. coli, with His labeled tag. The total length of FES Protein, Human (His) is 375 a.a..
FES, a tyrosine-protein kinase, functions downstream of cell surface receptors, contributing to the regulation of various cellular processes, including the actin cytoskeleton dynamics, microtubule assembly, cell attachment, and cell spreading. It plays a crucial role in FCER1-mediated signaling in mast cells, influencing mast cell degranulation, and acts downstream of the KIT receptor. Additionally, FES is involved in cell differentiation, promoting neurite outgrowth in response to NGF signaling. It contributes to cell scattering and migration triggered by HGF-induced activation of EZR. FES phosphorylates key proteins such as BCR, leading to the down-regulation of BCR kinase activity, as well as HCLS1/HS1, PECAM1, STAT3, and TRIM28, underscoring its diverse regulatory functions in cellular signaling pathways.
Technical Parameters
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Species Human
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Source E. coli
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Tag His
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Accession
P07332-1 (I448-R822)
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Gene ID2242
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Protein Length
Partial
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Synonyms
FES; Proto-Oncogene C-Fes; FES Proto-Oncogene, Tyrosine Kinase; Proto-Oncogene C-Fps; FPS; C-Fes/Fps Protein; Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog; P93c-Fes; Feline Sarcoma/Fujinami Av
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AA Sequence
IPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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