FRK Protein, Human (Active, sf9, GST)
FRK protein is a non-receptor tyrosine protein kinase that acts as a negative regulator of cell proliferation by positively regulating PTEN protein stability. Through phosphorylation of PTEN on “Tyr-336”, FRK may prevent PTEN ubiquitination and degradation by reducing its binding to NEDD4. FRK, Human (Active, sf9, GST) is the recombinant human-derived FRK protein, expressed by Sf9 insect cells, with labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
FRK protein is a non-receptor tyrosine protein kinase that acts as a negative regulator of cell proliferation by positively regulating PTEN protein stability. Through phosphorylation of PTEN on “Tyr-336”, FRK may prevent PTEN ubiquitination and degradation by reducing its binding to NEDD4. FRK, Human (Active, sf9, GST) is the recombinant human-derived FRK protein, expressed by Sf9 insect cells, with labeled tag.
Background
FRK Protein, a non-receptor tyrosine-protein kinase, exerts its role as a negative regulator of cell proliferation. Its pivotal function involves the positive regulation of PTEN protein stability achieved through the phosphorylation of PTEN on 'Tyr-336'. This phosphorylation event prevents PTEN ubiquitination and degradation, potentially by reducing its binding to NEDD4. FRK Protein's ability to enhance PTEN stability suggests a regulatory mechanism that counteracts excessive cell proliferation, implying a potential tumor suppressor role for FRK Protein in cellular processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST
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Accession
P42685-1 (T223-R505)
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Gene ID2444
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Molecular Construction
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N-term
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GST
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FRK (T223-R505)
Accession # P42685-1 -
C-term
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Protein Length
Partial
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Synonyms
FRK; PTK5 Protein Tyrosine Kinase 5; Prev. PTK5; Protein-Tyrosine Kinase 5; RAK; Fyn-Related Kinase; GTK; Fyn-Related Src Family Tyrosine Kinase; Nuclear Tyrosine Protein Kinase RAK; FYN-Related Kinase; Fyn Related Src Family Tyrosine Kinase; Tyrosine-Pro
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AA Sequence
TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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