FRK
FRK (fyn-related kinase, formerly known as GTK, BSK or Iyk) is a Src-family-related kinase that is exceptional within the family: it lacks the N-terminal myristoylation signal, so it resides mainly in the nucleus and cytoplasm rather than at membranes, and it carries a distinctive C-terminal region. FRK is highly expressed in breast, colon and hematopoietic cells and generally behaves as a negative regulator of cell growth. It phosphorylates and stabilizes p53, dampens STAT3 signaling, and inhibits proliferation of breast and colon cancer cells, a profile opposite to most Src-family kinases. Consequently, FRK has been characterized as a candidate tumor suppressor whose expression is reduced in some breast tumors, rather than as a drug target.
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FRK Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
