MARK1 Protein, Human (Active, His)
MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag.
MARK1, a serine/threonine-protein kinase, plays a crucial role in cellular processes, particularly in the regulation of cell polarity and microtubule dynamics. It achieves this by phosphorylating microtubule-associated proteins such as DCX, MAP2, MAP4, and MAPT/TAU, causing their detachment from microtubules and subsequent disassembly. In the context of neuronal migration, MARK1's dual activities in regulating cellular polarity and microtubule dynamics, potentially through the phosphorylation and regulation of DCX, contribute to its involvement in this process. Furthermore, MARK1 acts as a positive regulator of the Wnt signaling pathway, likely by mediating the phosphorylation of disheveled proteins (DVL1, DVL2, and/or DVL3), adding another layer to its multifaceted role in cellular regulation.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q9P0L2 (N45-L795, ΔS383-S681, K761S, R764S)
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Gene ID4139
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Molecular Construction
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N-term
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6*His
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MARK1 (N45-L795, ΔS383-S681, K761S, R764S)
Accession # Q9P0L2 -
C-term
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Protein Length
Partial
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Synonyms
MARK1; PAR1 Homolog C; Microtubule Affinity Regulating Kinase 1; Par1c; MAP/Microtubule Affinity-Regulating Kinase 1; MAP/Microtubule Affinity-Regulating Kinase 1 Isoform A; MARK; Non-Specific Serine/Threonine Protein Kinase; Serine/Threonine-Protein Kina
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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