SRPK3 Protein, Human (Active, sf9, GST)

SRPK3 Protein precisely modulates cellular processes by phosphorylating substrates in RS domains. In vitro studies reveal SRPK3's activity on key targets, including SRSF1 and LBR, underscoring its indispensable role in normal muscle development. SRPK3's significance extends beyond molecular interactions, emphasizing its integral part in orchestrating intricate biological pathways for muscle maturation. SRPK3 Protein, Human (sf9, GST) is the recombinant human-derived SRPK3 protein, expressed by Sf9 insect cells , with GST labeled tag.

SRPK3, a serine/arginine-rich protein-specific kinase, intricately modulates cellular processes by selectively phosphorylating substrates at serine residues within arginine/serine dipeptide-rich regions, designated as RS domains. In vitro studies highlight SRPK3's phosphorylation activity on key targets such as the SR splicing factor SRSF1 and the lamin-B receptor (LBR). The significance of SRPK3 extends beyond molecular interactions, as it proves indispensable for normal muscle development, emphasizing its integral role in the intricate orchestration of biological pathways governing muscle maturation.

Human

Sf9 insect cells

GST

Q9UPE1-4/NP_001164231.1 (M1-P566)

26576  [NCBI]

Full Length of Isoform-4

MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.