SRPK3 - SRSF protein kinase 3 Gene

Also Known as MSSK1; STK23; MSSK-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26576

About SRPK3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,781,041-153,785,730 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues and 19 paralogues. Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues.

Summary

This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

SRPK3 Products (3)

mRNA Protein Name
NM_001170760.2 NP_001164231.1 SRSF protein kinase 3 isoform 2
NM_001170761.2 NP_001164232.1 SRSF protein kinase 3 isoform 3
NM_014370.4 NP_055185.2 SRSF protein kinase 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23602568 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (79 - 221)

Pkinase

Pkinase: Protein kinase domain (402 - 565)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 567 a.a.
Protein Preferred Names Protein Names

SRSF protein kinase 3

  • SFRS protein kinase 3

SRPK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRPK3 Q9UPE1 SRPK1 Homo sapiens Q96SB4
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SRPK3 Proteins

Cat. No. Product Name Accession Purity
HY-P76659 SRPK3 Protein, Human (Active, sf9, GST) Q9UPE1-4/NP_001164231.1 (M1-P566) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Tonne-Kalscheuer Syndrome

  • TOKAS

  • Mrx61

  • Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia

  • Mental Retardation, X-Linked 61

  • X-Linked Mental Retardation 61
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148518 MSC-1186 Inhibitor 98.95% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-RS13779 SRPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19039 Srpk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25528 Srpk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRPK3 RGD RGD:727856
Macaca mulatta SRPK3 VGNC VGNC:77914
Bos taurus SRPK3 VGNC VGNC:35290
Mus musculus SRPK3 MGD MGI:1891338
Canis familiaris SRPK3 VGNC VGNC:46812
Others SRPK3 NCBI