TLK2 Protein, Human (Active, sf9, His, GST)
TLK2 is an important serine/threonine protein kinase with complex effects on chromatin assembly, DNA replication, transcription, repair, and chromosome segregation. It plays multiple roles by phosphorylating and stabilizing chromatin assembly factors such as ASF1A and ASF1B, preventing proteasome-mediated degradation. TLK2 Protein, Human (749a.a, sf9, His, GST) is the recombinant human-derived TLK2, expressed by Sf9 insect cells, with His, GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TLK2 is an important serine/threonine protein kinase with complex effects on chromatin assembly, DNA replication, transcription, repair, and chromosome segregation. It plays multiple roles by phosphorylating and stabilizing chromatin assembly factors such as ASF1A and ASF1B, preventing proteasome-mediated degradation. TLK2 Protein, Human (749a.a, sf9, His, GST) is the recombinant human-derived TLK2, expressed by Sf9 insect cells, with His, GST labeled tag.
Background
TLK2, a serine/threonine-protein kinase, plays a crucial role in the intricate processes of chromatin assembly, potentially extending its influence to DNA replication, transcription, repair, and chromosome segregation. This kinase exhibits a multifaceted role by phosphorylating chromatin assembly factors, including ASF1A and ASF1B, and contributing to their stabilization, particularly through the prevention of proteasome-mediated degradation. By enhancing chromatin assembly, TLK2 actively participates in the maintenance of genomic integrity. Additionally, TLK2 functions as a negative regulator of amino acid starvation-induced autophagy, showcasing its involvement in cellular responses to nutritional cues. This versatile kinase, with its impact on fundamental cellular processes, emerges as a key player in the intricate orchestration of various aspects of nuclear and cellular dynamics.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-8*His;N-GST
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Accession
Q86UE8-1 (M2-S750)
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Gene ID11011
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Protein Length
Partial
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Synonyms
TLK2; MGC44450; Tousled Like Kinase 2; HsHPK; PKU-ALPHA; Non-Specific Serine/Threonine Protein Kinase; Serine/Threonine-Protein Kinase Tousled-Like 2; PKU-Alpha; Tousled-Like Kinase 2; MRD57
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AA Sequence
MEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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