MARK1 Protein, Human (Active, ΔS383-S681, K761S, R764S)
MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free.
Background
MARK1, a serine/threonine-protein kinase, plays a crucial role in cellular processes, particularly in the regulation of cell polarity and microtubule dynamics. It achieves this by phosphorylating microtubule-associated proteins such as DCX, MAP2, MAP4, and MAPT/TAU, causing their detachment from microtubules and subsequent disassembly. In the context of neuronal migration, MARK1's dual activities in regulating cellular polarity and microtubule dynamics, potentially through the phosphorylation and regulation of DCX, contribute to its involvement in this process. Furthermore, MARK1 acts as a positive regulator of the Wnt signaling pathway, likely by mediating the phosphorylation of disheveled proteins (DVL1, DVL2, and/or DVL3), adding another layer to its multifaceted role in cellular regulation.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9P0L2 (N45-L795, ΔS383-S681, K761S, R764S)
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Gene ID4139
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Molecular Construction
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N-term
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MARK1 (N45-L795, ΔS383-S681, K761S, R764S)
Accession # Q9P0L2 -
C-term
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Protein Length
Partial
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Synonyms
MARK1; PAR1 Homolog C; Microtubule Affinity Regulating Kinase 1; Par1c; MAP/Microtubule Affinity-Regulating Kinase 1; MAP/Microtubule Affinity-Regulating Kinase 1 Isoform A; MARK; Non-Specific Serine/Threonine Protein Kinase; Serine/Threonine-Protein Kinase MARK1; KIAA1477; PAR-1C; Par-1c
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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