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Cat. No.: HY-137658

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Purine riboside triphosphate

(Synonyms: PTP)

Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC₅₀ values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a K_i value of 590 µM.

For research use only. We do not sell to patients.

CAS No.: 23197-96-8
Formula: C₁₀H₁₅N₄O₁₃P₃
Molecular Weight:492.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Purine riboside triphosphate Chemical Structure

CAS No.: 23197-96-8

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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

All CaMK Isoforms :

Chemical Information

CAS No. 23197-96-8
Molecular Weight 492.17
Formula C₁₀H₁₅N₄O₁₃P₃
SMILES

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O)N2C3=NC=NC=C3N=C2
Synonyms

PTP
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. [Content Brief]

[2]. Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. [Content Brief]

[3]. Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Purine riboside triphosphate

All DNA/RNA Synthesis Isoforms

All CaMK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Purine riboside triphosphate Related Classifications

HY-137658 Related Classifications