Purine riboside-5'-O-triphosphate sodium
Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.
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- CAS No.: 35892-95-6
- Formula: C10H11N4Na4O13P3
- Molecular Weight:580.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
Chemical Information
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CAS No. 35892-95-6
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Molecular Weight 580.09
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Formula C10H11N4Na4O13P3
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SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)N2C3=NC=NC=C3N=C2
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Synonyms
PTP tetrasodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. [Content Brief]
[2]. Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. [Content Brief]
[3]. Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purine riboside-5'-O-triphosphate sodium Related Classifications
HY-137658A Related Classifications
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