35892-95-6
Chemical Structure
Purine riboside-5'-O-triphosphate sodium
Synonym(s): PTP tetrasodium
- CAS No.: 35892-95-6
- Formula:C10H11N4Na4O13P3
- Molecular Weight:580.09
IUPAC Name: sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(9H-purin-9-yl)tetrahydrofuran-2-yl)methyl triphosphate
InChIKey: MVLIGYOSEAYNOT-KLZZHCBDSA-J
SMILES: O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)N2C3=NC=NC=C3N=C2
Biological Activity: Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM[1][2][3].
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Purine riboside-5'-O-triphosphate sodium | Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM. | |||||||||||||||||||||
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References
- [1]. Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. [Content Brief]
- [2]. Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. [Content Brief]
- [3]. Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640. [Content Brief]
