PIP4K2B Protein, Human (Active)
PIP4K2B protein actively synthesizes phosphatidylinositol 4,5-bisphosphate and preferentially selects GTP over ATP in PI(5)P phosphorylation. The enzyme activity is related to physiological GTP levels. Its unique GTP-sensing ability is critical for metabolic adaptation. PIP4K2B, Human (Active) is the recombinant human-derived PIP4K2B protein, expressed by E. coli, with N-Avi labeled tag.
- Species: Human
- Source: E. coli
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Product Properties
- Help & FAQs
Biological Activity
PIP4K2B protein actively synthesizes phosphatidylinositol 4,5-bisphosphate and preferentially selects GTP over ATP in PI(5)P phosphorylation. The enzyme activity is related to physiological GTP levels. Its unique GTP-sensing ability is critical for metabolic adaptation. PIP4K2B, Human (Active) is the recombinant human-derived PIP4K2B protein, expressed by E. coli, with N-Avi labeled tag.
PIP4K2B Protein actively participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate, demonstrating a preference for GTP over ATP in the phosphorylation of PI(5)P, and its enzymatic activity is intricately linked to physiological GTP concentrations. The protein's unique GTP-sensing ability plays a critical role in metabolic adaptation. Notably, PIP4Ks, including PIP4K2B, exert a negative regulatory influence on insulin signaling through a catalytic-independent mechanism. They form interactions with PIP5Ks, effectively suppressing PIP5K-mediated synthesis of PtdIns(4,5)P2 and impeding insulin-dependent conversion to PtdIns(3,4,5)P3. This multifaceted role underscores the importance of PIP4K2B in modulating key signaling pathways that contribute to cellular homeostasis and metabolic responsiveness.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag Tag Free
-
Accession
P78356-1 (S2-T416)
-
Gene ID8396
-
Molecular Construction
-
N-term
-
(S2-T416)
Accession # P78356-1 -
C-term
-
-
Protein Length
Full Length
-
Synonyms
PIP4K2B; Diphosphoinositide Kinase 2-Beta; Prev. PIP5K2B; PIP4KII-Beta; PIP5KIIbeta; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta; PIP5KIIB; 1-Phosphatidylinositol-4-Phosphate Kinase; Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta; P
-
AA Sequence
SSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
