1. MAPK/ERK Pathway
  2. MEK


Cat. No.: HY-12467 Purity: 98.08%
Handling Instructions

OTS964 is a potent TOPK inhibitor with an IC50 value of 28 nM.

For research use only. We do not sell to patients.
OTS-964 Chemical Structure

OTS-964 Chemical Structure

CAS No. : 1338545-07-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 226 In-stock
2 mg USD 132 In-stock
5 mg USD 240 In-stock
10 mg USD 336 In-stock
25 mg USD 660 In-stock
50 mg USD 1020 In-stock
100 mg USD 1800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


OTS964 is a potent TOPK inhibitor with an IC50 value of 28 nM. IC50 value: 28 nM Target: TOPK in vitro: OTS964 is a dimethylated derivative of OTS514. OTS964 can inhibit TOPK kinase activity with high affinity and selectivity. TOPK (T-lymphokine-activated killer cell-originated protein kinase) is a protein that is found in a wide range of human cancers and is believed to work as an oncogene, promoting tumor growth. OTS964 inhibits the growth of TOPK-positive cells with low IC50 values [A549 (31 nM), LU-99 (7.6 nM), DU4475 (53 nM), MDA-MB-231 (73 nM), T47D (72 nM), Daudi (25 nM), UM-UC-3 (32 nM), HCT-116(33nM), MKN1(38nM), MKN45(39nM), HepG2(19nM), MIAPaca-2 (30 nM), and 22Rv1 (50 nM)]. [1] in vivo: OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), OTS964 causes a cytokinesis defect and the subsequent apoptosis of cancer cells in xenograft models of human lung cancer.

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3312 mL 11.6558 mL 23.3117 mL
5 mM 0.4662 mL 2.3312 mL 4.6623 mL
10 mM 0.2331 mL 1.1656 mL 2.3312 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







OC1=CC(C)=C2C(C3=C(SC=C3)C(N2)=O)=C1C4=CC=C([[email protected]@H](C)CN(C)C)C=C4.Cl

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.08%

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