Search Result

Results for "

ampk-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (334) 11β-HSD (3) Acetyl-CoA Carboxylase (10) ADC Payload (3) Adenosine Receptor (2) Adiponectin Receptor (1) Adrenergic Receptor (4) Akt (54) Amylases (1) Amyloid-β (5) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Annexin A (1) Antibiotic (3) AP-1 (2) Apoptosis (114) Atg8/LC3 (1) ATP Citrate Lyase (7) ATP Synthase (1) Aurora Kinase (3) Autophagy (89) Bacterial (30) Bcl-2 Family (11) Beclin1 (2) Beta-secretase (2) Biochemical Assay Reagents (4) c-Myc (2) Calcium Channel (8) Calmodulin (1) CaMK (4) Cannabinoid Receptor (1) Casein Kinase (2) Caspase (21) Checkpoint Kinase (Chk) (1) Chloride Channel (6) Cholinesterase (ChE) (7) Clathrin (1) Collagen (1) COX (14) Cytochrome P450 (1) Dengue Virus (1) Deubiquitinase (1) Dipeptidyl Peptidase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (4) DOCK (3) Dopamine Receptor (1) Drug Derivative (6) Drug Isomer (1) Drug Metabolite (5) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (4) Elastase (1) Endogenous Metabolite (34) Enolase (1) Environmental Pollutants (8) Ephrin Receptor (3) Epigenetic Reader Domain (2) Epoxide Hydrolase (2) ERK (14) FABP (1) FAK (1) FASTK (1) Fatty Acid Synthase (FASN) (1) FBPase (1) Ferroptosis (10) FLT3 (2) Fluorescent Dye (4) FOXO (3) Free Fatty Acid Receptor (1) Fructose-1,6-bisphosphate aldolase (1) Fungal (14) FXR (2) GHSR (1) Glucocorticoid Receptor (1) GLUT (8) Glycosidase (1) GSK-3 (6) HBV (3) HDAC (5) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (6) Hippo (MST) (1) Histone Demethylase (1) HIV (3) HSP (3) HSV (2) Hydroxycarboxylic Acid Receptor (HCAR) (1) IAP (1) IFNAR (1) IKK (2) Insecticide (4) Insulin Receptor (1) Interleukin Related (22) Isotope-Labeled Compounds (25) JAK (11) JNK (20) Keap1-Nrf2 (17) Kinesin (1) Lactate Dehydrogenase (1) LDLR (1) Lipase (1) MAPKAPK2 (MK2) (1) MARK (2) MDM-2/p53 (8) MEK (2) Microsomal Triglyceride Transfer Protein (MTP) (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (16) Mitophagy (16) MMP (8) MNK (1) Monoamine Oxidase (1) mTOR (45) MyD88 (1) NAMPT (2) NF-κB (49) NO Synthase (7) NOD-like Receptor (NLR) (11) Notch (1) Nuclear Factor of activated T Cells (NFAT) (4) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (4) Organoid (3) Oxidative Phosphorylation (3) P2Y Receptor (2) p38 MAPK (33) Parasite (23) PARP (8) PD-1/PD-L1 (1) PDGFR (1) PEPCK (1) PERK (7) PGC-1α (8) Phosphatase (3) PI3K (26) Pim (2) PINK1/Parkin (3) PKA (5) PKC (9) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (5) PPAR (30) Pyroptosis (6) Quinone Reductase (1) Ras (1) Reactive Oxygen Species (ROS) (44) Reference Standards (69) Ribosomal S6 Kinase (RSK) (5) ROCK (1) Salt-inducible Kinase (SIK) (4) SARS-CoV (5) Ser/Thr Kinase (1) Sirtuin (22) Small Interfering RNA (siRNA) (4) SOD (9) Src (2) STAT (21) Stearoyl-CoA Desaturase (SCD) (1) STING (2) Survivin (3) TGF-beta/Smad (5) TGF-β Receptor (4) TNF Receptor (17) Toll-like Receptor (TLR) (3) Topoisomerase (4) TRP Channel (2) Tyrosinase (5) ULK (2) VDAC (1) VEGFR (10) Virus Protease (3) Wnt (5) YAP (5) α-synuclein (1) β-catenin (2)
By Research Areas:	Cancer (182) Cardiovascular Disease (68) Endocrinology (12) Infection (58) Inflammation/Immunology (118) Metabolic Disease (208) Neurological Disease (94)
Oligonucleotides:	Nucleoside Analogs (2) Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) Cholesterol (1) siRNAs (4)

413

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

161

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

AICAR 210+ Cited Publications Acadesine; AICA Riboside	AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

A-769662 40+ Cited Publications	AMPK	Metabolic Disease
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC₅₀ = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC₅₀ = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .

MK8722 20+ Cited Publications	AMPK	Metabolic Disease
MK8722 is a potent and systemic *pan-AMPK* activator.

Bempedoic acid 20+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates *AMPK* .

PF-06409577 1 Publications Verification	AMPK	Metabolic Disease
PF-06409577 is a potent and selective allosteric activator of *AMPK* α1β1γ1 isoform with an EC₅₀ of 7 nM.

AICAR phosphate 210+ Cited Publications Acadesine phosphate; AICA Riboside phosphate	AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a *AMPK* activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

O-304 5 Publications Verification	AMPK	Cardiovascular Disease Metabolic Disease
O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .

Metformin-d6 hydrochloride 1,1-Dimethylbiguanide-d6 hydrochloride	Isotope-Labeled Compounds AMPK Autophagy Mitophagy Apoptosis mTOR	Cardiovascular Disease Metabolic Disease
Metformin-d₆ hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to *AMPK* activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating *AMPK* and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

AMPK-IN-3 5 Publications Verification	AMPK	Cancer
AMPK-IN-3 (compound 67) is a potent and selective *AMPK* inhibitor with IC₅₀s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits *AMPK* does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer .

Chromium(III) acetate 2 Publications Verification Chromium acetate; Chromic acetate; Chromium triacetate	Environmental Pollutants AMPK	Metabolic Disease
Chromium(III) acetate (Chromic acetate) is an *AMPK* inhibitor that promotes lipogenesis by inhibiting *AMPK* phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD₅₀ of 2365 mg/kg in rats .

Danthron 4 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	AMPK Autophagy Bacterial Virus Protease	Cancer
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating *AMPK*.

Rhapontin 2 Publications Verification Rhaponiticin	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and *AMPK* activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

PF-739	AMPK	Metabolic Disease
PF-739 is an orally active and non-selective activator of *AMPK. PF-739 activates 12 heterotrimeric AMPK* complexes and significantly reduces the level of glucose in plasma complexes .

MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively . MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells . MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .

Aurantio-obtusin 1 Publications Verification	TNF Receptor COX	Cardiovascular Disease Inflammation/Immunology
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .

Indoprofen (±)-Indoprofe	Akt AMPK NF-κB p38 MAPK	Inflammation/Immunology
Indoprofen ((±)-Indoprofe) activates *AKT-AMPK* signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active .

Lixumistat acetate 1 Publications Verification IM156; HL156A; HL271 acetate	Mitochondrial Metabolism AMPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Lixumistat (IM156) acetate is a potent and orally active *AMPK* activator and OXPHOS inhibitor. Lixumistat acetate strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat acetate exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .

MK-3903 3 Publications Verification	AMPK	Metabolic Disease
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC₅₀ of 8 nM.

YLF-466D 2 Publications Verification C24	AMPK	Cancer
YLF-466D is a newly developed *AMPK* activator, which inhibits platelet aggregation.

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Environmental Pollutants AMPK Bacterial Tyrosinase	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the *CaMKK2-AMPK* signaling pathway .

Mogrol 2 Publications Verification	ERK STAT	Cancer
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating *AMPK* signaling.

Wu-5 1 Publications Verification	FLT3 AMPK Apoptosis Deubiquitinase	Cancer
Wu-5 is a USP10 inhibitor that can inhibit FLT3 and *AMPK* pathways, induce FLT3-ITD degradation and induce apoptosis .

STF-118804 2 Publications Verification	NAMPT AMPK mTOR	Cancer
STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates *AMPK* and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer .

ZLN024 hydrochloride 1 Publications Verification	AMPK	Metabolic Disease
ZLN024 hydrochloride is an *AMPK* allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

Ampkinone 3 Publications Verification	AMPK	Metabolic Disease
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

Biguanide	Mitochondrial Metabolism AMPK Insulin Receptor	Metabolic Disease Cancer
Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the *LKB1-AMPK* signaling pathway, and damages the energy homeostasis. Biguanide enhances insulin-receptor activation and downstream signaling. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers.

Cimiracemoside C Cimicifugoside M	AMPK	Metabolic Disease
Cimiracemoside C is an active component of Cimicifuga racemosa, activates *AMPK*, has the potential activity against diabetes .

PF-06685249 PF-249	AMPK	Metabolic Disease
PF-06685249 (PF-249) is a potent and orally active allosteric *AMPK* activator with an EC₅₀ of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 improves renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 can be used for diabetic nephropathy research .

RSVA405 1 Publications Verification	AMPK STAT Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology
RSVA405 is a potent, orally active activator of *AMPK, with an EC₅₀* of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .

Ginkgolide K	Autophagy	Neurological Disease
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

ASP4132 1 Publications Verification	AMPK	Cancer
ASP4132 is an orally active, potent *AMPK* activator with an EC₅₀ of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models .

Marein 3 Publications Verification	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

AMPK activator 4	AMPK	Metabolic Disease
AMPK activator 4 is a potent *AMPK* activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

7-Methoxyisoflavone 4 Publications Verification	AMPK	Metabolic Disease Cancer
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

Lixumistat 1 Publications Verification IM156 free base; HL156A free base; HL271 free base	Mitochondrial Metabolism AMPK	Neurological Disease Inflammation/Immunology
Lixumistat (IM156 free base) is a potent and orally active *AMPK* activator and OXPHOS inhibitor. Lixumistat strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .

Malvidin-3-O-arabinoside chloride 1 Publications Verification	AMPK Autophagy	Metabolic Disease Inflammation/Immunology
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy .

AMPK-IN-4	AMPK	Cancer
AMPK-IN-4 (compound 19) is a potent inhibitor of (AMPK(α1) and *AMPK*(α2) with IC₅₀s of 393 nM and 141 nM, respectively. AMPK-IN-4 plays an important role in cancer research .

AMPK activator 13	AMPK	Metabolic Disease
AMPK activator 13 is a potent activator of *AMPK. AMPK* activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .

AMPK activator 12	AMPK	Cancer
AMPK activator 12 (compound 21) is a potent *AMPK* activator and GDF15 inducer. AMPK activator 12 increases GDF15 protein levels in human hepatic cells .

PT1	AMPK	Cardiovascular Disease Metabolic Disease
PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers .

Lixumistat hydrochloride 1 Publications Verification HL271; IM156 hydrochloride; HL156A hydrochloride	Mitochondrial Metabolism AMPK	Neurological Disease
Lixumistat (IM156) hydrochloride is a potent and orally active *AMPK* activator and OXPHOS inhibitor. Lixumistat hydrochloride strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat hydrochloride exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .

Kazinol U	AMPK	Others
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of *AMPK* (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates *AMPK* signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

Cat. No.	Product Name

HY-L040

Anti-diabetic Compound Library

1,113 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 1,113 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

HY-L034

Anti-Aging Compound Library

7,297 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 7,297 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L037

Antioxidant Compound Library

2,332 compounds

Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. Oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body aging process and cause acute pathologies. Antioxidants are a class of compounds able to counteract oxidative stress and mitigate its effects on individuals’ health, gained enormous attention from the biomedical research community. Antioxidants have long been substantial and amenable therapeutic arsenals for multifarious diseases such as AD and cancer.

MCE Antioxidant Compound Library contains 2,332 compounds that act as antioxidants for high throughput screening (HTS) and high content screening (HCS). This library is a useful tool for discovery new antioxidants and oxidative stress research.

HY-L034M

Anti-Aging Compound Library Mini

381 compounds

Research has shown that drugs targeting aging pathways demonstrate promising potential in models of age-related diseases such as Alzheimer's disease, cardiovascular diseases, metabolic syndrome, osteoarthritis, and various malignancies. This suggests that intervening in the biological processes of aging may enable synergistic prevention and treatment of multiple chronic diseases. Against the backdrop of the gradual elucidation of core aging mechanisms-including cellular senescence, telomere attrition, epigenetic dysregulation, and chronic inflammation anti-aging research has shifted from traditional phenotypic interventions toward targeting key pathways that regulate biological age.

The MCE Anti-Aging Compound Library Mini is precisely built upon this cutting-edge concept. It focuses on aging-related targets validated through genetic or functional studies, comprising 381 compounds designed to provide systematic research tools for aging biology and intervention strategy development. The library covers core mechanisms such as mTOR, SIRT, energy metabolism, clearance of senescent cells, optimization of mitochondrial function, and telomere maintenance. For each target, 1-5 compounds with clear activity and strong representativeness have been carefully selected, spanning the entire translational spectrum from preclinical tool molecules to clinically investigational drugs.

HY-L015

PI3K/Akt/mTOR Compound Library

1,049 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 1,049 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Cat. No.	Product Name	Type

HY-13418G

Dorsomorphin dihydrochloride

Compound C dihydrochloride; BML-275 dihydrochloride

Fluorescent Dye

Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-P0136AF

FAM-SAMS TFA	Fluorescent Dye
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

Cat. No.	Product Name	Type

HY-Y1325H

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al

4 Publications Verification

Biochemical Assay Reagents

Sodium acetate trihydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-Y0319G

Magnesium acetate tetrahydrate

4 Publications Verification

Biochemical Assay Reagents

Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-W011012

Adenosine 5'-monophosphate disodium

Maximum Cited Publications

18 Publications Verification

Biochemical Assay Reagents

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W338584

Hydroxycitric acid tripotassium

1 Publications Verification

Biochemical Assay Reagents

Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-A0144A

Etilefrine hydrochloride

Biochemical Assay Reagents

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-13418G

Dorsomorphin dihydrochloride

Compound C dihydrochloride; BML-275 dihydrochloride

Biochemical Assay Reagents

HY-Y0319D

Acetic acid lead

Biochemical Assay Reagents

Acetic acid lead is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Acetic acid lead exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Acetic acid lead regulates energy metabolism. Acetic acid lead has anticancer activity against gastric cancer. Acetic acid lead induces writhing reaction and ulcerative colitis. Acetic acid lead can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-137782

Palmitoleoyl-CoA	Biochemical Assay Reagents
Palmitoleoyl-CoA can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA regulates metabolism via allosteric control of AMPK β1-isoforms .

HY-Y0319G1

Magnesium acetate tetrahydrate, for molecular biology

Biochemical Assay Reagents

Magnesium acetate tetrahydrate, for molecular biology is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate, for molecular biology activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate, for molecular biology exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate, for molecular biology regulates energy metabolism. Magnesium acetate tetrahydrate, for molecular biology has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate, for molecular biology induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate, for molecular biology can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

HY-A0144AR

Etilefrine hydrochloride (Standard)

Biochemical Assay Reagents

Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-W011012R

Adenosine 5'-monophosphate disodium (Standard)

Biochemical Assay Reagents

Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P2048

MOTS-c (human) 1 Publications Verification	Apoptosis GLUT AMPK	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the *AMPK/PGC-1α* pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate *AMPK, and then regulates the Nrf2/Keap1* antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces *p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

HY-30216A

Leucic acid α-Hydroxyisocaproic acid	Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK	Metabolic Disease Inflammation/Immunology
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters *AMPK* and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .

HY-P2048A

MOTS-c(human) acetate 1 Publications Verification	AMPK GLUT	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the *AMPK/PGC-1α* pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate *AMPK, and then regulates the Nrf2/Keap1* antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-P10769

MOTS-c (mouse) 2 Publications Verification	AMPK Apoptosis	Metabolic Disease
MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through *AMPK* activation .

HY-P0136

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

HY-P1576A

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

HY-P0136AF

FAM-SAMS TFA	Fluorescent Dye	Others
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-P1797A

Sakamototide substrate peptide TFA	Peptides	Others
Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays .

HY-P1576

AMARA peptide	Salt-inducible Kinase (SIK) AMPK	Inflammation/Immunology
AMARA peptide is a substrate for SIK and AMPK.

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-P0136F

FAM-SAMS	AMPK	Others
FAM-SAMS is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P1385

TCS 183	GSK-3 p38 MAPK	Neurological Disease
TCS 183, a peptide, is a GSK-3β inhibitor. TCS 183 blocks GSK-3β autoinhibition and decreases the level of *AMPK* phosphorylation. TCS 183 can be used for neuropathological diseases, particularly Alzheimer’s disease, research .

HY-P10367

Ziptide	MAPKAPK2 (MK2) Checkpoint Kinase (Chk) AMPK	Others
Ziptide is a substrate for MAPK activated protein kinase 2 (MAPKAPK2, K_m = 5 μM), MAPKAPK3 (K_m = 30 μM), PARK (K_m = 40 μM), checkpoint kinase 1 (Chk1, K_m = 5 μM), AMP-activated protein kinase (AMPK, K_m = 75 μM), and calcium/calmodulin-dependent protein kinase II (CamKII, K_m = 300 μM) .

Recombinant Proteins Recommended:

AMPK

Species:	Human (9)
Tag:	His (8) Strep (1) GST (7)
Source:	Sf9 insect cells (9)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702978

	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (Inactive, sf9, His) Subunits A2: PRKAA2; ampk; ampk2; PRKAA Subunit B1: PRKAB1; ampk; Hampkb; MGC17785 Subunit G1: PRKAG1; ampkG; MGC866	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK (gamma 1/beta 1/alpha 2) Protein, Human (Unactive, sf9, His) is the recombinant human-derived AMPK (gamma 1/beta 1/alpha 2), expressed by Sf9 insect cells, with His labeled tag.

HY-P76141

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (Active, sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; ampk; ampk (α1, β1, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of 38 (beta-1)&40 (gamma-1)&95 (alpha-1) kDa, respectively.

HY-P76142

	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (Active, sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; ampk; ampk (α2, β1, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 2 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST, N-10*His labeled tag. AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~40 & 42 & 95 KDa, respectively.

HY-P76144

	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (Active, sf9, His-GST) 5'-AMP-activated protein kinase; ampk; ampk (α2, β2, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 2 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.

HY-P76143

	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (Active, sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; ampk; ampk (α1, β2, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.

HY-P705564

	AMPK alpha-2/beta-1/gamma-3 Heterotrimer Protein, Human (Active, sf9, His, GST) 5'-AMP-activated protein kinase; ampk; ampk (α2, β1, γ3) Protein	Human	Sf9 insect cells

HY-P702896

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (Active, sf9, His) ampk1	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Protein, Human (sf9, His) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1, expressed by Sf9 insect cells, with C-6*His labeled tag.

HY-P702979

	AMPKG1 Protein, Human (sf9, GST) 5'-AMP-activated protein kinase subunit gamma-1; ampk gamma1; ampk subunit gamma-1; ampkg; PRKAG1	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPKG1 Protein, Human (sf9, GST) is the recombinant human-derived AMPKG1, expressed by Sf9 insect cells, with GST labeled tag. The total length of AMPKG1 Protein, Human (sf9, GST) is 331 a.a..

HY-P706003

	NUAK1 Protein, Human (Active, sf9, His-GST) NUAK family SNF1-like kinase 1; ampk-related protein kinase 5 (ARK5); Omphalocele kinase 1; ARK5; KIAA0537; OMPHK1; EC:2.7.11.1	Human	Sf9 insect cells

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Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (14) Rabbit (16)
Reactivity:	Human (30) Rat (17) Mouse (15) Monkey (5) Rabbit (2)
Application:	IHC-P (19) ICC/IF (19) IP (12) WB (26) FC (11) ELISA (11)
Isotype:	IgG,Kappa (1) IgG (15) IgG1 (9)
Conjugation:	Non-conjugated (30)
Clonality:	Polyclonal (4) Monoclonal (18) Recombinant (7)
Modification:	Phosphorylated (5) Unmodified (17)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84394

	AMPK alpha 2 Antibody (YA4091) ampk; ampk2; PRKAA; ampka2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	AMPK alpha 2 Antibody (YA4091) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 2.

HY-P84394A

	AMPK alpha 2 Antibody (YA4091)(PBS only) ampk; ampk2; PRKAA; ampka2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	AMPK alpha 2 Antibody (YA4091) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 2.

HY-P84528

	AMPK alpha 1 Antibody (YA4225) ampk; ampka1; MGC33776; MGC57364; PRKAA1	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	AMPK alpha 1 Antibody (YA4225) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 1.

HY-P84528A

	AMPK alpha 1 Antibody (YA4225)(PBS only) ampk; ampka1; MGC33776; MGC57364; PRKAA1	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	AMPK alpha 1 Antibody (YA4225) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 1.

HY-P85578

	AMPK beta 1 Antibody (YA5270) 1300015D22Rik; 5 AMP activated protein kinase subunit beta 1; 5''-AMP-activated protein kinase subunit beta-1; AAKB1_HUMAN; AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1; AMP-activated, noncatalytic, beta-1; ampk; ampk beta 1 chain; ampk subunit beta-1; ampk-BETA-1; ampkb; AU021155; E430008F22; Hampkb; MGC17785; PRKAB1.	WB, ICC/IF, IP, IHC-P	Human, Mouse, Rat, Monkey
	AMPK beta 1 Antibody (YA5270) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK beta 1.

HY-P80542

	AMPK beta 1 Antibody 5' ' -AMP-activated protein kinase subunit beta-1; AMP-activated; noncatalytic; beta-1; ampk; ampk beta 1 chain; ampk subunit beta-1; ampk-BETA-1; ampkb; Hampkb; PRKAB1	WB, IHC-P, FC, IP	Human, Mouse, Rat
	AMPK beta 1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AMPK beta 1.

HY-P85706

	AMPK gamma 1 Antibody (YA5398) 5'-AMP-activated protein kinase subunit gamma-1; ampk gamma1; ampk subunit gamma-1; ampkg;	IHC-P, WB	Human, Mouse, Rat
	AMPK gamma 1 Antibody (YA5398) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK gamma 1.

HY-P80541

	AMPK alpha 2 Antibody (YA622) 2 Publications Verification PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human
	AMPK alpha 2 Antibody (YA622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80791

	*Phospho-AMPK* alpha 2 (Thr172) Antibody** 1 Publications Verification PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human, Mouse, Rat
	Phospho-AMPK alpha 2 (Thr172) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AMPK alpha 2 (Thr172).

HY-P80540

	AMPK alpha 2 Antibody (YA623) PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human, Rat
	AMPK alpha 2 Antibody (YA623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80540A

	AMPK alpha 2 Antibody (YA623)(PBS only) PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human, Rat
	AMPK alpha 2 Antibody (YA623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80541A

	AMPK alpha 2 Antibody (YA622)(PBS only) PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human
	AMPK alpha 2 Antibody (YA622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P810580

	*Phospho-AMPK* alpha 2 (Ser491) Antibody (YA9844)** PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human
	Phospho-AMPK alpha 2 (Ser491) Antibody (YA9844) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AMPK alpha 2 (Ser491).

HY-P80791A

	*Phospho-AMPK* alpha 2 (Thr172) Antibody(YA9953)** PRKAA2; ampk; ampk2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ampk subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human, Mouse, Rat
	Phospho-AMPK alpha 2 (Thr172) Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AMPK alpha 2 (Thr172).

HY-P87895

	AMPK α1 Antibody (YA7580)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	AMPK α1 Antibody (YA7580) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to AMPK α1.

HY-P85709

	AMPK beta 2 Antibody (YA5401) 5'-AMP-activated protein kinase subunit beta-2; ampk subunit beta-2;	IHC-P, WB	Human, Mouse, Rat
	AMPK beta 2 Antibody (YA5401) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK beta 2.

HY-P80452

	*Phospho-AMPK* alpha 2(Ser345) Antibody (YA225)** 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse
	Phospho-AMPK alpha 2(Ser345) Antibody (YA225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AMPK alpha 2(Ser345).

HY-P80376

	AMPK alpha 1 Antibody (YA624)	WB, ICC/IF, FC, IP	Human, Rat
	AMPK alpha 1 Antibody (YA624) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 1.

HY-P80377

	AMPK alpha 2 Antibody (YA833)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	AMPK alpha 2 Antibody (YA833) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 2.

HY-P83848

	AMPK beta 2 Antibody (YA3545)	IHC-P, ICC/IF, FC, ELISA	Human
	AMPK beta 2 Antibody (YA3545) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK beta 2.

HY-P85708

	AMPK beta 1 Antibody (YA5400) 5'-AMP-activated protein kinase subunit beta-1; ampk subunit beta-1; ampkb;	IHC-P, WB	Human, Mouse, Rat
	AMPK beta 1 Antibody (YA5400) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK beta 1.

HY-P80543

	AMPK gamma 1 Antibody (YA621) ampkG	WB, ICC/IF, IP	Human
	AMPK gamma 1 Antibody (YA621) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK gamma 1.

HY-P84393

	AMPK gamma 1 Antibody (YA4090) ampkG	IHC-P, ICC/IF, FC, ELISA	Human
	AMPK gamma 1 Antibody (YA4090) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK gamma 1.

HY-P80539

	AMPK alpha 1 Antibody PRKAA1; ampk1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; ampk subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	AMPK alpha 1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AMPK alpha 1.

HY-P83848A

	AMPK beta 2 Antibody (YA3545)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
	AMPK beta 2 Antibody (YA3545) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK beta 2.

HY-P85745

	AMPK alpha 1 Antibody (YA5437) PRKAA1; ampk1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; ampk subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	AMPK alpha 1 Antibody (YA5437) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK alpha 1.

HY-P80790

	*Phospho-AMPK* alpha 1 (Ser496) Antibody** PRKAA1; ampk1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; ampk subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AMPK alpha 1 (Ser496).

HY-P80451

	*Phospho-AMPK* alpha 1 (Ser496) Antibody (YA226)**	WB, ICC/IF, IP	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody (YA226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AMPK alpha 1 (Ser496).

HY-P80543A

	AMPK gamma 1 Antibody (YA621)(PBS only) ampkG	WB, ICC/IF, IP	Human
	AMPK gamma 1 Antibody (YA621) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK gamma 1.

HY-P84393A

	AMPK gamma 1 Antibody (YA4090)(PBS only) ampkG	IHC-P, ICC/IF, FC, ELISA	Human
	AMPK gamma 1 Antibody (YA4090) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK gamma 1.

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Host
Reactivity
Application
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Clonality
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Appearance
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Gene ID
SwissProt ID
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Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-N0131

Stigmasterol 10+ Cited Publications		Cholesterol
Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates *AMPK, which in turn inhibits NF-κB* and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others .

HY-W011527

Xanthosine 3 Publications Verification		Nucleoside Analogs
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research .

HY-RS11100

PRKAA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAA1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-W013803

Xanthosine dihydrate		Nucleoside Analogs
Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research .

HY-RS11102

PRKAB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11101

PRKAA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKAA2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27694

Prkaa2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prkaa2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkaa2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

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