2. Epigenetics PI3K/Akt/mTOR NF-κB
  3. AMPK Keap1-Nrf2
  4. Ethyl (E)-ferulate

Ethyl (E)-ferulate is an AMPK/Nrf2 signaling pathway activator that can reduce lipopolysaccharide (HY-D1056)-induced acute lung injury. Additionally, Ethyl (E)-ferulate exhibits free radical scavenging properties, providing anti-inflammatory, antioxidant, neuroprotective, and sunscreen effects. Ethyl (E)-ferulate holds promise for research in the fields of inflammation and neurodegenerative diseases.

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Ethyl (E)-ferulate

Ethyl (E)-ferulate Chemical Structure

CAS No. : 28028-62-8

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Ethyl (E)-ferulate Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

Ethyl (E)-ferulate is an AMPK/Nrf2 signaling pathway activator that can reduce lipopolysaccharide (HY-D1056)-induced acute lung injury. Additionally, Ethyl (E)-ferulate exhibits free radical scavenging properties, providing anti-inflammatory, antioxidant, neuroprotective, and sunscreen effects. Ethyl (E)-ferulate holds promise for research in the fields of inflammation and neurodegenerative diseases[1][2][3].

Cellular Effect
Cell Line Type Value Description References
A549 GI50
1.2 μM
Compound: 11
Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
[PMID: 21106458]
A549 IC50
12.5 μM
Compound: 1b
Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay
Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
Calu-1 IC50
>50 μM
Compound: 1b
Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay
Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
HeLa GI50
52.8 μM
Compound: 11
Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
[PMID: 21106458]
HeLa IC50
2.13 μM
Compound: 1b
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
[PMID: 22954735]
HOP-62 IC50
26.8 μM
Compound: 1b
Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay
Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
LOX IMVI IC50
>50 μM
Compound: 1b
Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay
Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay
[PMID: 22954735]
M14 IC50
>50 μM
Compound: 1b
Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay
Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
MCF7 GI50
86.3 μM
Compound: 11
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
[PMID: 21106458]
MT4 CC50
>10 μM
Compound: 9
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 3 days by CytoTox-Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 3 days by CytoTox-Glo assay
[PMID: 26756779]
MT4 EC50
>10 μM
Compound: 9
Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in viral replication measured on day 3 post infection by luciferase reporter gene assay
Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in viral replication measured on day 3 post infection by luciferase reporter gene assay
[PMID: 26756779]
NCI-H1299 IC50
36.8 μM
Compound: 1b
Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H157 IC50
32.3 μM
Compound: 1b
Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H1792 IC50
25.6 μM
Compound: 1b
Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay
Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
NCI-H460 IC50
29.1 μM
Compound: 1b
Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
[PMID: 22954735]
Platelet IC50
193.2 μM
Compound: Ethyl ferulate
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
10.1039/C4MD00022F
SK-N-SH GI50
22.3 μM
Compound: 11
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
[PMID: 21106458]
Molecular Weight

222.24

Formula

C12H14O4
CAS No.
SMILES

CCOC(/C=C/C1=CC(OC)=C(C=C1)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ethyl (E)-ferulate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl (E)-ferulate28028-62-8AMPKKeap1-Nrf2AMP-activated protein kinaseAnti-inflammatoryAntioxidantNeuroprotectiveInhibitorinhibitorinhibit

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